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@ARTICLE{Dembek:874715,
      author       = {Dembek, Till A. and Petry-Schmelzer, Jan Niklas and Reker,
                      Paul and Wirths, Jochen and Hamacher, Stefanie and Steffen,
                      Julia and Dafsari, Haidar S. and Hövels, Mauritius and
                      Fink, Gereon Rudolf and Visser-Vandewalle, Veerle and Barbe,
                      Michael T.},
      title        = {{PSA} and {VIM} {DBS} efficiency in essential tremor
                      depends on distance to the dentatorubrothalamic tract},
      journal      = {NeuroImage: Clinical},
      volume       = {26},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2020-01627},
      pages        = {102235 -},
      year         = {2020},
      abstract     = {ObjectiveTo investigate the relation between deep brain
                      stimulation (DBS) of the posterior-subthalamic-area (PSA)
                      and the ventral-intermediate-nucleus (VIM) and the distance
                      to the dentatorubrothalamic tract (DRTT) in essential tremor
                      (ET).MethodsTremor rating scale (TRS) hemi-scores were
                      analyzed in 13 ET patients, stimulated in both the VIM and
                      the PSA in a randomized, crossover trial. Distances of PSA
                      and VIM contacts to population-based DRTTs were calculated.
                      The relationships between distance to DRTT and stimulation
                      amplitude, as well as DBS efficiency (TRS improvement per
                      amplitude) were investigated.ResultsPSA contacts were closer
                      to the DRTT (p = 0.019) and led to a greater improvement in
                      TRS hemi-scores (p = 0.005) than VIM contacts. Proximity to
                      the DRTT was related to lower amplitudes (p < 0.001) and
                      higher DBS efficiency (p = 0.017).ConclusionsDifferences in
                      tremor outcome and stimulation parameters between contacts
                      in the PSA and the VIM can be explained by their different
                      distance to the DRTT.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32172171},
      UT           = {WOS:000533149400053},
      doi          = {10.1016/j.nicl.2020.102235},
      url          = {https://juser.fz-juelich.de/record/874715},
}