TY  - JOUR
AU  - Kiesow, Hannah
AU  - Dunbar, Robin I. M.
AU  - Kable, Joseph W.
AU  - Kalenscher, Tobias
AU  - Vogeley, Kai
AU  - Schilbach, Leonhard
AU  - Marquand, Andre F.
AU  - Wiecki, Thomas V.
AU  - Bzdok, Danilo
TI  - 10,000 social brains: Sex differentiation in human brain anatomy
JO  - Science advances
VL  - 6
IS  - 12
SN  - 2375-2548
CY  - Washington, DC [u.a.]
PB  - Assoc.
M1  - FZJ-2020-01640
SP  - eaaz1170 -
PY  - 2020
AB  - In human and nonhuman primates, sex differences typically explain much interindividual variability. Male and female behaviors may have played unique roles in the likely coevolution of increasing brain volume and more complex social dynamics. To explore possible divergence in social brain morphology between men and women living in different social environments, we applied probabilistic generative modeling to ~10,000 UK Biobank participants. We observed strong volume effects especially in the limbic system but also in regions of the sensory, intermediate, and higher association networks. Sex-specific brain volume effects in the limbic system were linked to the frequency and intensity of social contact, such as indexed by loneliness, household size, and social support. Across the processing hierarchy of neural networks, different conditions for social interplay may resonate in and be influenced by brain anatomy in sex-dependent ways.
LB  - PUB:(DE-HGF)16
C6  - pmid:32206722
UR  - <Go to ISI:>//WOS:000521937000033
DO  - DOI:10.1126/sciadv.aaz1170
UR  - https://juser.fz-juelich.de/record/874731
ER  -