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000874827 1001_ $$00000-0003-4885-5051$$aDanilenko, Nataliya$$b0
000874827 245__ $$aHistone chaperone exploits intrinsic disorder to switch acetylation specificity
000874827 260__ $$a[London]$$bNature Publishing Group UK$$c2019
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000874827 520__ $$aHistones, the principal protein components of chromatin, contain long disordered sequences, which are extensively post-translationally modified. Although histone chaperones are known to control both the activity and specificity of histone-modifying enzymes, the mechanisms promoting modification of highly disordered substrates, such as lysine-acetylation within the N-terminal tail of histone H3, are not understood. Here, to understand how histone chaperones Asf1 and Vps75 together promote H3 K9-acetylation, we establish the solution structural model of the acetyltransferase Rtt109 in complex with Asf1 and Vps75 and the histone dimer H3:H4. We show that Vps75 promotes K9-acetylation by engaging the H3 N-terminal tail in fuzzy electrostatic interactions with its disordered C-terminal domain, thereby confining the H3 tail to a wide central cavity faced by the Rtt109 active site. These fuzzy interactions between disordered domains achieve localization of lysine residues in the H3 tail to the catalytic site with minimal loss of entropy, and may represent a common mechanism of enzymatic reactions involving highly disordered substrates
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000874827 65017 $$0V:(DE-MLZ)GC-1602-2016$$2V:(DE-HGF)$$aPolymers, Soft Nano Particles and Proteins$$x0
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000874827 7001_ $$0P:(DE-HGF)0$$aLercher, Lukas$$b1
000874827 7001_ $$00000-0002-9761-3377$$aKirkpatrick, John$$b2
000874827 7001_ $$00000-0003-3446-2601$$aGabel, Frank$$b3
000874827 7001_ $$0P:(DE-HGF)0$$aCodutti, Luca$$b4
000874827 7001_ $$00000-0002-2437-2760$$aCarlomagno, Teresa$$b5$$eCorresponding author
000874827 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-019-11410-7$$gVol. 10, no. 1, p. 3435$$n1$$p3435$$tNature Communications$$v10$$x2041-1723$$y2019
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