000874827 001__ 874827
000874827 005__ 20210130004813.0
000874827 0247_ $$2doi$$a10.1038/s41467-019-11410-7
000874827 0247_ $$2Handle$$a2128/24625
000874827 0247_ $$2altmetric$$aaltmetric:64626057
000874827 0247_ $$2pmid$$apmid:31387991
000874827 0247_ $$2WOS$$aWOS:000478866600001
000874827 037__ $$aFZJ-2020-01660
000874827 082__ $$a500
000874827 1001_ $$00000-0003-4885-5051$$aDanilenko, Nataliya$$b0
000874827 245__ $$aHistone chaperone exploits intrinsic disorder to switch acetylation specificity
000874827 260__ $$a[London]$$bNature Publishing Group UK$$c2019
000874827 3367_ $$2DRIVER$$aarticle
000874827 3367_ $$2DataCite$$aOutput Types/Journal article
000874827 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1585725530_27240
000874827 3367_ $$2BibTeX$$aARTICLE
000874827 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000874827 3367_ $$00$$2EndNote$$aJournal Article
000874827 520__ $$aHistones, the principal protein components of chromatin, contain long disordered sequences, which are extensively post-translationally modified. Although histone chaperones are known to control both the activity and specificity of histone-modifying enzymes, the mechanisms promoting modification of highly disordered substrates, such as lysine-acetylation within the N-terminal tail of histone H3, are not understood. Here, to understand how histone chaperones Asf1 and Vps75 together promote H3 K9-acetylation, we establish the solution structural model of the acetyltransferase Rtt109 in complex with Asf1 and Vps75 and the histone dimer H3:H4. We show that Vps75 promotes K9-acetylation by engaging the H3 N-terminal tail in fuzzy electrostatic interactions with its disordered C-terminal domain, thereby confining the H3 tail to a wide central cavity faced by the Rtt109 active site. These fuzzy interactions between disordered domains achieve localization of lysine residues in the H3 tail to the catalytic site with minimal loss of entropy, and may represent a common mechanism of enzymatic reactions involving highly disordered substrates
000874827 536__ $$0G:(DE-HGF)POF3-6G4$$a6G4 - Jülich Centre for Neutron Research (JCNS) (POF3-623)$$cPOF3-623$$fPOF III$$x0
000874827 536__ $$0G:(DE-HGF)POF3-6G15$$a6G15 - FRM II / MLZ (POF3-6G15)$$cPOF3-6G15$$fPOF III$$x1
000874827 588__ $$aDataset connected to CrossRef
000874827 65027 $$0V:(DE-MLZ)SciArea-160$$2V:(DE-HGF)$$aBiology$$x0
000874827 65017 $$0V:(DE-MLZ)GC-1602-2016$$2V:(DE-HGF)$$aPolymers, Soft Nano Particles and  Proteins$$x0
000874827 693__ $$0EXP:(DE-MLZ)KWS1-20140101$$1EXP:(DE-MLZ)FRMII-20140101$$5EXP:(DE-MLZ)KWS1-20140101$$6EXP:(DE-MLZ)NL3b-20140101$$aForschungs-Neutronenquelle Heinz Maier-Leibnitz $$eKWS-1: Small angle scattering diffractometer$$fNL3b$$x0
000874827 7001_ $$0P:(DE-HGF)0$$aLercher, Lukas$$b1
000874827 7001_ $$00000-0002-9761-3377$$aKirkpatrick, John$$b2
000874827 7001_ $$00000-0003-3446-2601$$aGabel, Frank$$b3
000874827 7001_ $$0P:(DE-HGF)0$$aCodutti, Luca$$b4
000874827 7001_ $$00000-0002-2437-2760$$aCarlomagno, Teresa$$b5$$eCorresponding author
000874827 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-019-11410-7$$gVol. 10, no. 1, p. 3435$$n1$$p3435$$tNature Communications$$v10$$x2041-1723$$y2019
000874827 8564_ $$uhttps://juser.fz-juelich.de/record/874827/files/s41467-019-11410-7.pdf$$yOpenAccess
000874827 8564_ $$uhttps://juser.fz-juelich.de/record/874827/files/s41467-019-11410-7.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000874827 909CO $$ooai:juser.fz-juelich.de:874827$$pdnbdelivery$$pVDB$$pVDB:MLZ$$pdriver$$popen_access$$popenaire
000874827 9131_ $$0G:(DE-HGF)POF3-623$$1G:(DE-HGF)POF3-620$$2G:(DE-HGF)POF3-600$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF3-6G4$$aDE-HGF$$bForschungsbereich Materie$$lVon Materie zu Materialien und Leben$$vFacility topic: Neutrons for Research on Condensed Matter$$x0
000874827 9131_ $$0G:(DE-HGF)POF3-6G15$$1G:(DE-HGF)POF3-6G0$$2G:(DE-HGF)POF3-600$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$9G:(DE-HGF)POF3-6G15$$aDE-HGF$$bForschungsbereich Materie$$lGroßgeräte: Materie$$vFRM II / MLZ$$x1
000874827 9141_ $$y2020
000874827 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000874827 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000874827 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000874827 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record
000874827 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT COMMUN : 2017
000874827 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bNAT COMMUN : 2017
000874827 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal
000874827 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000874827 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000874827 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000874827 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences
000874827 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000874827 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000874827 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review
000874827 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences
000874827 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000874827 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000874827 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000874827 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central
000874827 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000874827 920__ $$lyes
000874827 9201_ $$0I:(DE-Juel1)JCNS-FRM-II-20110218$$kJCNS-FRM-II$$lJCNS-FRM-II$$x0
000874827 9201_ $$0I:(DE-Juel1)JCNS-2-20110106$$kJCNS-2$$lStreumethoden$$x1
000874827 9201_ $$0I:(DE-588b)4597118-3$$kMLZ$$lHeinz Maier-Leibnitz Zentrum$$x2
000874827 9201_ $$0I:(DE-Juel1)JCNS-1-20110106$$kJCNS-1$$lNeutronenstreuung$$x3
000874827 980__ $$ajournal
000874827 980__ $$aVDB
000874827 980__ $$aUNRESTRICTED
000874827 980__ $$aI:(DE-Juel1)JCNS-FRM-II-20110218
000874827 980__ $$aI:(DE-Juel1)JCNS-2-20110106
000874827 980__ $$aI:(DE-588b)4597118-3
000874827 980__ $$aI:(DE-Juel1)JCNS-1-20110106
000874827 9801_ $$aFullTexts