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000874902 0247_ $$2doi$$a10.1002/jmri.27136
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000874902 1001_ $$00000-0002-3254-4809$$aLennartz, Simon$$b0$$eCorresponding author
000874902 245__ $$aMRI Follow-up of Astrocytoma: Automated Coregistration and Color-Coding of FLAIR Sequences Improves Diagnostic Accuracy With Comparable Reading Time
000874902 260__ $$aNew York, NY$$bWiley-Liss$$c2020
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000874902 520__ $$aBackgroundMRI follow‐up is widely used for longitudinal assessment of astrocytoma, yet reading can be tedious and error‐prone, in particular when changes are subtle.Purpose/HypothesisTo determine the effect of automated, color‐coded coregistration (AC) of fluid attenuated inversion recovery (FLAIR) sequences on diagnostic accuracy, certainty, and reading time compared to conventional follow‐up MRI assessment of astrocytoma patients.Study TypeRetrospective.PopulationIn all, 41 patients with neuropathologically confirmed astrocytoma.Field Strength/Sequence1.0–3.0T/FLAIRAssessmentThe presence or absence of tumor progression was determined based on FLAIR sequences, contrast‐enhanced T1 sequences, and clinical data. Three radiologists assessed 47 MRI study pairs in a conventional reading (CR) and in a second reading supported by AC after 6 weeks. Readers determined the presence/absence of tumor progression and indicated diagnostic certainty on a 5‐point Likert scale. Reading time was recorded by an independent assessor.Statistical TestsThe Wilcoxon test was used to assess reading time and diagnostic certainty. Differences in diagnostic accuracy, sensitivity, and specificity were analyzed with the McNemar mid‐p test.ResultsReaders attained significantly higher overall sensitivity (0.86 vs. 0.75; P < 0.05) and diagnostic accuracy (0.84 vs. 0.73; P < 0.05) for detection of progressive nonenhancing tumor burden when using AC compared to CR. There was a strong trend towards higher specificity within the AC‐augmented reading, yet without statistical significance (0.83 vs. 0.71; P = 0.08). Sensitivity for unequivocal disease progression was similarly high in both approaches (AC: 0.94, CR: 0.92), while for marginal disease progressions, it was significantly higher in AC (AC: 0.78, CR: 0.58; P < 0.05). Reading time including application loading time was comparable (AC: 38.1 ± 16.8 sec, CR: 36.0 ± 18.9 s; P = 0.25).Data ConclusionCompared to CR, AC improves comparison of FLAIR signal hyperintensity at MRI follow‐up of astrocytoma patients, allowing for a significantly higher diagnostic accuracy, particularly for subtle disease progression at a comparable reading time.
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000874902 7001_ $$0P:(DE-HGF)0$$aZopfs, David$$b1
000874902 7001_ $$0P:(DE-HGF)0$$aNobis, Anne$$b2
000874902 7001_ $$0P:(DE-HGF)0$$aPaquet, Stefanie$$b3
000874902 7001_ $$0P:(DE-HGF)0$$aHoyer, Ulrike Cornelia Isabel$$b4
000874902 7001_ $$00000-0003-3746-8523$$aZäske, Charlotte$$b5
000874902 7001_ $$0P:(DE-HGF)0$$aGoertz, Lukas$$b6
000874902 7001_ $$0P:(DE-HGF)0$$aKabbasch, Christoph$$b7
000874902 7001_ $$0P:(DE-HGF)0$$aLaukamp, Kai Roman$$b8
000874902 7001_ $$0P:(DE-HGF)0$$aGroße Hokamp, Nils$$b9
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000874902 7001_ $$0P:(DE-HGF)0$$aBorggrefe, Jan$$b11
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