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@ARTICLE{Galldiks:874903,
      author       = {Galldiks, Norbert and Werner, Jan-Michael and Tscherpel,
                      Caroline and Fink, Gereon R and Langen, Karl-Josef},
      title        = {{I}maging findings following regorafenib in malignant
                      gliomas: {FET} {PET} adds valuable information to anatomical
                      {MRI}},
      journal      = {Neuro-oncology advances},
      volume       = {1},
      number       = {1},
      issn         = {2632-2498},
      address      = {Oxford},
      publisher    = {Oxford University Press},
      reportid     = {FZJ-2020-01691},
      pages        = {vdz038},
      year         = {2019},
      abstract     = {The prospective REGOMA phase 2 trial showed an encouraging
                      and significant median progression-free and overall survival
                      (PFS, OS) benefit for glioblastoma patients at first
                      progression treated with the oral multikinase inhibitor
                      regorafenib compared to lomustine monotherapy.1 In
                      particular, the OS benefit was 1.8 months compared to
                      lomustine (7.4 vs. 5.6 months; P = .0009), and the hazard
                      ratio was 0.5 $(95\%$ confidence interval, 0.33–0.75).
                      Interestingly, despite unchanged MRI findings at first
                      follow-up (“Stable Disease,” $39\%)$ following
                      regorafenib, complete or partial radiological responses
                      according to the RANO criteria2 were only seen in $5\%$ of
                      cases treated with regorafenib. On the other hand, $59\%$ of
                      patients in the regorafenib arm had grade 3–4 adverse
                      events.},
      cin          = {INM-3 / INM-4},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-4-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32642667},
      UT           = {WOS:000886002700031},
      doi          = {10.1093/noajnl/vdz038},
      url          = {https://juser.fz-juelich.de/record/874903},
}