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024 7 _ |a 10.1093/noajnl/vdz038
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037 _ _ |a FZJ-2020-01691
100 1 _ |a Galldiks, Norbert
|0 P:(DE-Juel1)143792
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|e Corresponding author
245 _ _ |a Imaging findings following regorafenib in malignant gliomas: FET PET adds valuable information to anatomical MRI
260 _ _ |a Oxford
|c 2019
|b Oxford University Press
264 _ 1 |3 online
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|b Oxford University Press (OUP)
|c 2019-10-20
264 _ 1 |3 print
|2 Crossref
|b Oxford University Press (OUP)
|c 2019-05-01
264 _ 1 |3 print
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|c 2019-05-01
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336 7 _ |a Journal Article
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520 _ _ |a The prospective REGOMA phase 2 trial showed an encouraging and significant median progression-free and overall survival (PFS, OS) benefit for glioblastoma patients at first progression treated with the oral multikinase inhibitor regorafenib compared to lomustine monotherapy.1 In particular, the OS benefit was 1.8 months compared to lomustine (7.4 vs. 5.6 months; P = .0009), and the hazard ratio was 0.5 (95% confidence interval, 0.33–0.75). Interestingly, despite unchanged MRI findings at first follow-up (“Stable Disease,” 39%) following regorafenib, complete or partial radiological responses according to the RANO criteria2 were only seen in 5% of cases treated with regorafenib. On the other hand, 59% of patients in the regorafenib arm had grade 3–4 adverse events.
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542 _ _ |i 2019-10-20
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700 1 _ |a Werner, Jan-Michael
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700 1 _ |a Tscherpel, Caroline
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700 1 _ |a Fink, Gereon R
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700 1 _ |a Langen, Karl-Josef
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773 1 8 |a 10.1093/noajnl/vdz038
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|t Neuro-Oncology Advances
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999 C 5 |a 10.1016/S1470-2045(18)30675-2
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|t Lancet Oncol.
|v 20
|y 2019
999 C 5 |a 10.1200/JCO.2009.26.3541
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|1 Wen
|p 1963 -
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|t J Clin Oncol.
|v 28
|y 2010
999 C 5 |a 10.1093/neuonc/noz071
|1 Tzaridis
|y 2019
|2 Crossref
|t Neuro Oncol
|9 -- missing cx lookup --
999 C 5 |a 10.1007/s00432-019-02868-5
|9 -- missing cx lookup --
|1 Kebir
|p 1037 -
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|t J Cancer Res Clin Oncol.
|v 145
|y 2019
999 C 5 |a 10.1093/neuonc/now058
|9 -- missing cx lookup --
|1 Albert
|p 1199 -
|2 Crossref
|t Neuro Oncol.
|v 18
|y 2016
999 C 5 |a 10.1038/nrneurol.2017.44
|9 -- missing cx lookup --
|1 Langen
|p 279 -
|2 Crossref
|t Nat Rev Neurol.
|v 13
|y 2017


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