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@ARTICLE{Mohajer:874908,
      author       = {Mohajer, Bahram and Abbasi, Nooshin and Mohammadi, Esmaeil
                      and Khazaie, Habibolah and Osorio, Ricardo S. and
                      Rosenzweig, Ivana and Eickhoff, Claudia R. and Zarei,
                      Mojtaba and Tahmasian, Masoud and Eickhoff, Simon B.},
      title        = {{G}ray matter volume and estimated brain age gap are not
                      linked with sleep-disordered breathing},
      journal      = {Human brain mapping},
      volume       = {41},
      number       = {11},
      issn         = {1065-9471},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2020-01696},
      pages        = {3034-3044},
      year         = {2020},
      note         = {Funding informationNIH/NIA'a, Grant/Award
                      Numbers:R21AG055002, R01AG056531,R01AG056031; European
                      Union's Horizon2020 Research and Innovation
                      Programme,Grant/Award Number: 7202070; HelmholtzPortfolio
                      Theme; National Institute of MentalHealth; Deutsche
                      Forschungsgemeinschaft;University of Southern California;
                      NorthernCalifornia Institute for Research and
                      Education;Foundation for the National Institutes ofHealth;
                      Canadian Institutes of HealthResearch; Transition
                      Therapeutics; TakedaPharmaceutical Company; Servier;
                      PiramalImaging; Pfizer Inc; Novartis Pharm
                      aceuticalsCorporation; Neurotrack Technologies;NeuroRx
                      Research; Meso Scale Diag nostics,LLC; Merck $\&$ Co., Inc;
                      Lundb eck; Lumosity;Johnson $\&$ Johnson
                      PharmaceuticalResearch $\&$ Development LLC;
                      JanssenAlzheimer Immunotherapy Research $\&Development,$
                      LLC; IXICO Ltd; GE Healthcare;Fujirebio; Genentech, Inc; F.
                      Hoffmann-LaRoche Ltd; EuroImmun; Eli Lilly and Company;Eisai
                      Inc; Cogstate; CereSpir, Inc; Bristol-MyersSquibb Company;
                      Biogen; Araclon Biotech;BioClinica, Inc; Alzheimer's Drug
                      DiscoveryFoundation; AbbVie, Alzheimer's Associatio
                      n;National Institute of Biomedical Imaging
                      andBioengineering; National Institute on Aging;Department of
                      Defense, Grant/AwardNumber: W81XWH-12-20012;
                      NationalInstitutes of Health, Grant/Award
                      Numbers:R01-MH074457, U01 AG024904; ADNI},
      abstract     = {Alzheimer's disease (AD) and sleep-disordered breathing
                      (SDB) are prevalent conditions with a rising burden. It is
                      suggested that SDB may contribute to cognitive decline and
                      advanced aging. Here, we assessed the link between
                      self-reported SDB and gray matter volume in patients with
                      AD, mild cognitive impairment (MCI) and healthy controls
                      (HCs). We further investigated whether SDB was associated
                      with advanced brain aging. We included a total of 330
                      participants, divided based on self-reported history of SDB,
                      and matched across diagnoses for age, sex and presence of
                      the Apolipoprotein E4 allele, from the Alzheimer's Disease
                      Neuroimaging Initiative (ADNI). Gray-matter volume was
                      measured using voxel-wise morphometry and group differences
                      in terms of SDB, cognitive status, and their interaction
                      were assessed. Further, using an age-prediction model fitted
                      on gray-matter data of external datasets, we predicted study
                      participants' age from their structural images. Cognitive
                      decline and advanced age were associated with lower gray
                      matter volume in various regions, particularly in the
                      bilateral temporal lobes. Brains age was well predicted from
                      the morphological data in HCs and, as expected, elevated in
                      MCI and particularly in AD subjects. However, there was
                      neither a significant difference between regional gray
                      matter volume in any diagnostic group related to the SDB
                      status, nor in SDB-by-cognitive status interaction.
                      Moreover, we found no difference in estimated chronological
                      age gap related to SDB, or by-cognitive status interaction.
                      Contrary to our hypothesis, we were not able to find a
                      general or a diagnostic-dependent association of SDB with
                      either gray-matter volumetric or brain aging.},
      cin          = {INM-7 / INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406 / I:(DE-Juel1)INM-1-20090406},
      pnm          = {574 - Theory, modelling and simulation (POF3-574)},
      pid          = {G:(DE-HGF)POF3-574},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32239749},
      UT           = {WOS:000523248600001},
      doi          = {10.1002/hbm.24995},
      url          = {https://juser.fz-juelich.de/record/874908},
}