000874939 001__ 874939
000874939 005__ 20210130004827.0
000874939 0247_ $$2doi$$a10.1016/j.neuroimage.2020.116674
000874939 0247_ $$2ISSN$$a1053-8119
000874939 0247_ $$2ISSN$$a1095-9572
000874939 0247_ $$2Handle$$a2128/24673
000874939 0247_ $$2altmetric$$aaltmetric:76570775
000874939 0247_ $$2pmid$$apmid:32097724
000874939 0247_ $$2WOS$$aWOS:000525320500014
000874939 037__ $$aFZJ-2020-01711
000874939 082__ $$a610
000874939 1001_ $$0P:(DE-Juel1)169149$$aTrempler, Ima$$b0$$eCorresponding author
000874939 245__ $$aImpaired context-sensitive adjustment of behaviour in Parkinson’s disease patients tested on and off medication: An fMRI study
000874939 260__ $$aOrlando, Fla.$$bAcademic Press$$c2020
000874939 3367_ $$2DRIVER$$aarticle
000874939 3367_ $$2DataCite$$aOutput Types/Journal article
000874939 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1586331469_20308
000874939 3367_ $$2BibTeX$$aARTICLE
000874939 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000874939 3367_ $$00$$2EndNote$$aJournal Article
000874939 520__ $$aThe brain’s sensitivity to and accentuation of unpredicted over predicted sensory signals plays a fundamental role in learning. According to recent theoretical models of the predictive coding framework, dopamine is responsible for balancing the interplay between bottom-up input and top-down predictions by controlling the precision of surprise signals that guide learning.Using functional MRI, we investigated whether patients with Parkinson’s disease (PD) show impaired learning from prediction errors requiring either adaptation or stabilisation of current predictions. Moreover, we were interested in whether deficits in learning over a specific time scale would be accompanied by altered surprise responses in dopamine-related brain structures. To this end, twenty-one PD patients tested on and off dopaminergic medication and twenty-one healthy controls performed a digit prediction paradigm. During the task, violations of sequence-based predictions either signalled the need to update or to stabilise the current prediction and, thus, to react to them or ignore them, respectively. To investigate contextual adaptation to prediction errors, the probability (or its inverse, surprise) of the violations fluctuated across the experiment.When the probability of prediction errors over a specific time scale increased, healthy controls but not PD patients off medication became more flexible, i.e., error rates at violations requiring a motor response decreased in controls but increased in patients. On the neural level, this learning deficit in patients was accompanied by reduced signalling in the substantia nigra and the caudate nucleus. In contrast, differences between the groups regarding the probabilistic modulation of behaviour and neural responses were much less pronounced at prediction errors requiring only stabilisation but no adaptation. Interestingly, dopaminergic medication could neither improve learning from prediction errors nor restore the physiological, neurotypical pattern.Our findings point to a pivotal role of dysfunctions of the substantia nigra and caudate nucleus in deficits in learning from flexibility-demanding prediction errors in PD. Moreover, the data witness poor effects of dopaminergic medication on learning in PD.
000874939 536__ $$0G:(DE-HGF)POF3-572$$a572 - (Dys-)function and Plasticity (POF3-572)$$cPOF3-572$$fPOF III$$x0
000874939 588__ $$aDataset connected to CrossRef
000874939 7001_ $$0P:(DE-HGF)0$$aBürkner, Paul-Christian$$b1
000874939 7001_ $$0P:(DE-HGF)0$$aEl-Sourani, Nadiya$$b2
000874939 7001_ $$0P:(DE-Juel1)131716$$aBinder, Ellen$$b3
000874939 7001_ $$0P:(DE-HGF)0$$aReker, Paul$$b4
000874939 7001_ $$0P:(DE-Juel1)131720$$aFink, Gereon R.$$b5$$ufzj
000874939 7001_ $$0P:(DE-HGF)0$$aSchubotz, Ricarda I.$$b6
000874939 773__ $$0PERI:(DE-600)1471418-8$$a10.1016/j.neuroimage.2020.116674$$gVol. 212, p. 116674 -$$p116674 -$$tNeuroImage$$v212$$x1053-8119$$y2020
000874939 8564_ $$uhttps://juser.fz-juelich.de/record/874939/files/Trempler_2020_NeuroImage_Impaired%20context-sensitive%20adjustment%20of%20behaviour.pdf$$yOpenAccess
000874939 8564_ $$uhttps://juser.fz-juelich.de/record/874939/files/Trempler_2020_NeuroImage_Impaired%20context-sensitive%20adjustment%20of%20behaviour.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000874939 909CO $$ooai:juser.fz-juelich.de:874939$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000874939 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131716$$aForschungszentrum Jülich$$b3$$kFZJ
000874939 9101_ $$0I:(DE-HGF)0$$6P:(DE-Juel1)131716$$a INM-3$$b3
000874939 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131720$$aForschungszentrum Jülich$$b5$$kFZJ
000874939 9131_ $$0G:(DE-HGF)POF3-572$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$v(Dys-)function and Plasticity$$x0
000874939 9141_ $$y2020
000874939 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000874939 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000874939 915__ $$0StatID:(DE-HGF)0600$$2StatID$$aDBCoverage$$bEbsco Academic Search
000874939 915__ $$0LIC:(DE-HGF)CCBYNCND4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial-NoDerivs CC BY-NC-ND 4.0
000874939 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNEUROIMAGE : 2017
000874939 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000874939 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000874939 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000874939 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000874939 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bASC
000874939 915__ $$0StatID:(DE-HGF)9905$$2StatID$$aIF >= 5$$bNEUROIMAGE : 2017
000874939 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000874939 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000874939 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000874939 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000874939 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000874939 920__ $$lyes
000874939 9201_ $$0I:(DE-Juel1)INM-3-20090406$$kINM-3$$lKognitive Neurowissenschaften$$x0
000874939 980__ $$ajournal
000874939 980__ $$aVDB
000874939 980__ $$aUNRESTRICTED
000874939 980__ $$aI:(DE-Juel1)INM-3-20090406
000874939 9801_ $$aFullTexts