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@ARTICLE{Grasby:874988,
      author       = {Grasby, Katrina L and others},
      title        = {{T}he genetic architecture of the human cerebral cortex.},
      journal      = {Science / Science now Science now},
      volume       = {367},
      number       = {6484},
      issn         = {1095-9203},
      address      = {Washington, DC},
      publisher    = {Assoc.73085},
      reportid     = {FZJ-2020-01750},
      pages        = {1340},
      year         = {2020},
      abstract     = {The cerebral cortex underlies our complex cognitive
                      capabilities, yet little is known about the specific genetic
                      loci that influence human cortical structure. To identify
                      genetic variants that affect cortical structure, we
                      conducted a genome-wide association meta-analysis of brain
                      magnetic resonance imaging data from 51,665 individuals. We
                      analyzed the surface area and average thickness of the whole
                      cortex and 34 regions with known functional specializations.
                      We identified 199 significant loci and found significant
                      enrichment for loci influencing total surface area within
                      regulatory elements that are active during prenatal cortical
                      development, supporting the radial unit hypothesis. Loci
                      that affect regional surface area cluster near genes in Wnt
                      signaling pathways, which influence progenitor expansion and
                      areal identity. Variation in cortical structure is
                      genetically correlated with cognitive function, Parkinson's
                      disease, insomnia, depression, neuroticism, and attention
                      deficit hyperactivity disorder.},
      cin          = {INM-1},
      ddc          = {320},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571) / HBP SGA1 -
                      Human Brain Project Specific Grant Agreement 1 (720270) /
                      HBP SGA2 - Human Brain Project Specific Grant Agreement 2
                      (785907)},
      pid          = {G:(DE-HGF)POF3-571 / G:(EU-Grant)720270 /
                      G:(EU-Grant)785907},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32193296},
      UT           = {WOS:000522167400044},
      doi          = {10.1126/science.aay6690},
      url          = {https://juser.fz-juelich.de/record/874988},
}