TY  - JOUR
AU  - Stumme, Johanna
AU  - Jockwitz, Christiane
AU  - Hoffstaedter, Felix
AU  - Amunts, Katrin
AU  - Caspers, Svenja
TI  - Functional network reorganization in older adults: Graph-theoretical analyses of age, cognition and sex
JO  - NeuroImage
VL  - 214
SN  - 1053-8119
CY  - Orlando, Fla.
PB  - Academic Press
M1  - FZJ-2020-01751
SP  - 116756
PY  - 2020
AB  - Healthy aging has been associated with a decrease in functional network specialization. Importantly, variability of alterations of functional connectivity is especially high across older adults. Whole-brain functional network reorganization, though, and its impact on cognitive performance within particularly the older generation is still a matter of debate. We assessed resting state functional connectivity (RSFC) in 772 older adults (55-85 years, 421 males) using a graph-theoretical approach. Results show overall age-related increases of between- and decreases of within-network RSFC. With similar phenomena observed in young to middle-aged adults, i.e. that RSFC reorganizes towards more pronounced functional network integration, the current results amend such evidence for the old age. The results furthermore indicate that RSFC reorganization in older adults particularly pertain to early sensory networks (e.g. visual and sensorimotor network). Importantly, RSFC differences of these early sensory networks were found to be a relevant mediator in terms of the age-related cognitive performance differences. Further, we found systematic sex-related network differences with females showing patterns of more segregation (i.e. default mode and ventral attention network) and males showing a higher integrated network system (particularly for the sensorimotor network). These findings underpin the notion of sex-related connectivity differences, possibly facilitating sex-related behavioral functioning.
LB  - PUB:(DE-HGF)16
C6  - pmid:32201326
UR  - <Go to ISI:>//WOS:000540068600003
DO  - DOI:10.1016/j.neuroimage.2020.116756
UR  - https://juser.fz-juelich.de/record/874989
ER  -