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@ARTICLE{Stumme:874989,
      author       = {Stumme, Johanna and Jockwitz, Christiane and Hoffstaedter,
                      Felix and Amunts, Katrin and Caspers, Svenja},
      title        = {{F}unctional network reorganization in older adults:
                      {G}raph-theoretical analyses of age, cognition and sex},
      journal      = {NeuroImage},
      volume       = {214},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2020-01751},
      pages        = {116756},
      year         = {2020},
      abstract     = {Healthy aging has been associated with a decrease in
                      functional network specialization. Importantly, variability
                      of alterations of functional connectivity is especially high
                      across older adults. Whole-brain functional network
                      reorganization, though, and its impact on cognitive
                      performance within particularly the older generation is
                      still a matter of debate. We assessed resting state
                      functional connectivity (RSFC) in 772 older adults (55-85
                      years, 421 males) using a graph-theoretical approach.
                      Results show overall age-related increases of between- and
                      decreases of within-network RSFC. With similar phenomena
                      observed in young to middle-aged adults, i.e. that RSFC
                      reorganizes towards more pronounced functional network
                      integration, the current results amend such evidence for the
                      old age. The results furthermore indicate that RSFC
                      reorganization in older adults particularly pertain to early
                      sensory networks (e.g. visual and sensorimotor network).
                      Importantly, RSFC differences of these early sensory
                      networks were found to be a relevant mediator in terms of
                      the age-related cognitive performance differences. Further,
                      we found systematic sex-related network differences with
                      females showing patterns of more segregation (i.e. default
                      mode and ventral attention network) and males showing a
                      higher integrated network system (particularly for the
                      sensorimotor network). These findings underpin the notion of
                      sex-related connectivity differences, possibly facilitating
                      sex-related behavioral functioning.},
      cin          = {INM-1 / INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406 / I:(DE-Juel1)INM-7-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571) / HBP SGA2 -
                      Human Brain Project Specific Grant Agreement 2 (785907)},
      pid          = {G:(DE-HGF)POF3-571 / G:(EU-Grant)785907},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32201326},
      UT           = {WOS:000540068600003},
      doi          = {10.1016/j.neuroimage.2020.116756},
      url          = {https://juser.fz-juelich.de/record/874989},
}