TY  - JOUR
AU  - Michely, Jochen
AU  - Viswanathan, Shivakumar
AU  - Hauser, Tobias U.
AU  - Delker, Laura
AU  - Dolan, Raymond J.
AU  - Grefkes, Christian
TI  - The role of dopamine in dynamic effort-reward integration
JO  - Neuropsychopharmacology
VL  - 45
IS  - 9
SN  - 0893-133X
CY  - Basingstoke
PB  - Nature Publishing Group84063
M1  - FZJ-2020-01760
SP  - 1448-1453
PY  - 2020
AB  - When deciding to act, the neurotransmitter dopamine is implicated in a valuation of prospective effort and reward. However, its role in dynamic effort-reward integration during action, a process central to everyday behaviour, remains unclear. In a placebo-controlled, within-subject, study, we probed the impact of increasing brain dopamine levels (150 mg of levodopa) and blocking dopamine receptors (1.5 mg of haloperidol) in the context of a novel dynamic effort task in healthy human subjects. We show that modulating homoeostatic dopamine balance distinctly alters implicit and explicit effort allocation as a function of instantaneous reward. Pharmacologically boosting dopamine enhanced motor vigour, reflected in an implicit increase in effort allocation for high rewards. Conversely, pharmacological blockade of dopamine attenuated sensitivity to differences in reward context, reflected in reduced strategic effort discounting. These findings implicate dopamine in an integration of momentary physical experience and instantaneous reward, suggesting a key role of dopamine in acting to maximise reward on the fly.
LB  - PUB:(DE-HGF)16
C6  - pmid:32268344
UR  - <Go to ISI:>//WOS:000526237400001
DO  - DOI:10.1038/s41386-020-0669-0
UR  - https://juser.fz-juelich.de/record/875000
ER  -