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@ARTICLE{Michely:875000,
      author       = {Michely, Jochen and Viswanathan, Shivakumar and Hauser,
                      Tobias U. and Delker, Laura and Dolan, Raymond J. and
                      Grefkes, Christian},
      title        = {{T}he role of dopamine in dynamic effort-reward
                      integration},
      journal      = {Neuropsychopharmacology},
      volume       = {45},
      number       = {9},
      issn         = {0893-133X},
      address      = {Basingstoke},
      publisher    = {Nature Publishing Group84063},
      reportid     = {FZJ-2020-01760},
      pages        = {1448-1453},
      year         = {2020},
      abstract     = {When deciding to act, the neurotransmitter dopamine is
                      implicated in a valuation of prospective effort and reward.
                      However, its role in dynamic effort-reward integration
                      during action, a process central to everyday behaviour,
                      remains unclear. In a placebo-controlled, within-subject,
                      study, we probed the impact of increasing brain dopamine
                      levels (150 mg of levodopa) and blocking dopamine
                      receptors (1.5 mg of haloperidol) in the context of a
                      novel dynamic effort task in healthy human subjects. We show
                      that modulating homoeostatic dopamine balance distinctly
                      alters implicit and explicit effort allocation as a function
                      of instantaneous reward. Pharmacologically boosting dopamine
                      enhanced motor vigour, reflected in an implicit increase in
                      effort allocation for high rewards. Conversely,
                      pharmacological blockade of dopamine attenuated sensitivity
                      to differences in reward context, reflected in reduced
                      strategic effort discounting. These findings implicate
                      dopamine in an integration of momentary physical experience
                      and instantaneous reward, suggesting a key role of dopamine
                      in acting to maximise reward on the fly.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32268344},
      UT           = {WOS:000526237400001},
      doi          = {10.1038/s41386-020-0669-0},
      url          = {https://juser.fz-juelich.de/record/875000},
}