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@ARTICLE{Tuber:875083,
      author       = {Täuber, Sarah and von Lieres, Eric and Grünberger,
                      Alexander},
      title        = {{D}ynamic environmental control in microfluidic
                      single‐cell cultivations: {F}rom concepts to applications},
      journal      = {Small},
      volume       = {16},
      number       = {16},
      issn         = {1613-6829},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2020-01792},
      pages        = {1906670},
      year         = {2020},
      abstract     = {Microfluidic single‐cell cultivation (MSCC) is an
                      emerging field within fundamental as well as applied
                      biology. During the last years, most MSCCs were performed at
                      constant environmental conditions. Recently, MSCC at
                      oscillating and dynamic environmental conditions has started
                      to gain significant interest in the research community for
                      the investigation of cellular behavior. Herein, an overview
                      of this topic is given and microfluidic concepts that enable
                      oscillating and dynamic control of environmental conditions
                      with a focus on medium conditions are discussed, and their
                      application in single‐cell research for the cultivation of
                      both mammalian and microbial cell systems is demonstrated.
                      Furthermore, perspectives for performing MSCC at complex
                      dynamic environmental profiles of single parameters and
                      multiparameters (e.g., pH and O2) in amplitude and time are
                      discussed. The technical progress in this field provides
                      completely new experimental approaches and lays the
                      foundation for systematic analysis of cellular metabolism at
                      fluctuating environments.},
      cin          = {IBG-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {581 - Biotechnology (POF3-581)},
      pid          = {G:(DE-HGF)POF3-581},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32157796},
      UT           = {WOS:000530036200019},
      doi          = {10.1002/smll.201906670},
      url          = {https://juser.fz-juelich.de/record/875083},
}