%0 Journal Article
%A Beyer, Leonie
%A Nitschmann, Alexander
%A Barthel, Henryk
%A van Eimeren, Thilo
%A Unterrainer, Marcus
%A Sauerbeck, Julia
%A Marek, Ken
%A Song, Mengmeng
%A Palleis, Carla
%A Respondek, Gesine
%A Hammes, Jochen
%A Barbe, Michael T.
%A Onur, Özgür
%A Jessen, Frank
%A Saur, Dorothee
%A Schroeter, Matthias L.
%A Rumpf, Jost-Julian
%A Rullmann, Michael
%A Schildan, Andreas
%A Patt, Marianne
%A Neumaier, Bernd
%A Barret, Olivier
%A Madonia, Jennifer
%A Russell, David S.
%A Stephens, Andrew W.
%A Roeber, Sigrun
%A Herms, Jochen
%A Bötzel, Kai
%A Levin, Johannes
%A Classen, Joseph
%A Höglinger, Günter U.
%A Bartenstein, Peter
%A Villemagne, Victor
%A Drzezga, Alexander
%A Seibyl, John
%A Sabri, Osama
%A Brendel, Matthias
%T Early-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury
%J European journal of nuclear medicine and molecular imaging
%V 47
%@ 1619-7089
%C Heidelberg [u.a.]
%I Springer-Verl.
%M FZJ-2020-01803
%P 2911–2922
%D 2020
%X PurposeSecond-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [18F]PI-2620 as a potential substitute for [18F]fluorodeoxyglucose ([18F]FDG).MethodsTwenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer’s disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkinson’s disease, multi-system atrophy, Parkinson's disease, frontotemporal dementia) and received a dynamic [18F]PI-2620 tau-PET (0–60 min p.i.) and static [18F]FDG-PET (30–50 min p.i.). Regional standardized uptake value ratios of early-phase images (single frame SUVr) and the blood flow estimate (R1) of [18F]PI-2620-PET were correlated with corresponding quantification of [18F]FDG-PET (global mean/cerebellar normalization). Reduced tracer uptake in cortical target regions was also interpreted visually using 3-dimensional stereotactic surface projections by three more and three less experienced readers. Spearman rank correlation coefficients were calculated between early-phase [18F]PI-2620 tau-PET and [18F]FDG-PET images for all cortical regions and frequencies of disagreement between images were compared for both more and less experienced readers.ResultsHighest agreement with [18F]FDG-PET quantification was reached for [18F]PI-2620-PET acquisition from 0.5 to 2.5 min p.i. for global mean (lowest R = 0.69) and cerebellar scaling (lowest R = 0.63). Correlation coefficients (summed 0.5–2.5 min SUVr & R1) displayed strong agreement in all cortical target regions for global mean (RSUVr 0.76, RR1 = 0.77) and cerebellar normalization (RSUVr 0.68, RR1 = 0.68). Visual interpretation revealed high regional correlations between early-phase tau-PET and [18F]FDG-PET. There were no relevant differences between more and less experienced readers.ConclusionEarly-phase imaging of [18F]PI-2620 can serve as a surrogate biomarker for neuronal injury. Dynamic imaging or a dual time-point protocol for tau-PET imaging could supersede additional [18F]FDG-PET imaging by indexing both the distribution of tau and the extent of neuronal injury.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32318783
%U <Go to ISI:>//WOS:000528092500001
%R 10.1007/s00259-020-04788-w
%U https://juser.fz-juelich.de/record/875100