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000875100 0247_ $$2doi$$a10.1007/s00259-020-04788-w
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000875100 0247_ $$2ISSN$$a1619-7070
000875100 0247_ $$2ISSN$$a1619-7089
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000875100 1001_ $$0P:(DE-HGF)0$$aBeyer, Leonie$$b0
000875100 245__ $$aEarly-phase [18F]PI-2620 tau-PET imaging as a surrogate marker of neuronal injury
000875100 260__ $$aHeidelberg [u.a.]$$bSpringer-Verl.$$c2020
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000875100 520__ $$aPurposeSecond-generation tau radiotracers for use with positron emission tomography (PET) have been developed for visualization of tau deposits in vivo. For several β-amyloid and first-generation tau-PET radiotracers, it has been shown that early-phase images can be used as a surrogate of neuronal injury. Therefore, we investigated the performance of early acquisitions of the novel tau-PET radiotracer [18F]PI-2620 as a potential substitute for [18F]fluorodeoxyglucose ([18F]FDG).MethodsTwenty-six subjects were referred with suspected tauopathies or overlapping parkinsonian syndromes (Alzheimer’s disease, progressive supranuclear palsy, corticobasal syndrome, multi-system atrophy, Parkinson’s disease, multi-system atrophy, Parkinson's disease, frontotemporal dementia) and received a dynamic [18F]PI-2620 tau-PET (0–60 min p.i.) and static [18F]FDG-PET (30–50 min p.i.). Regional standardized uptake value ratios of early-phase images (single frame SUVr) and the blood flow estimate (R1) of [18F]PI-2620-PET were correlated with corresponding quantification of [18F]FDG-PET (global mean/cerebellar normalization). Reduced tracer uptake in cortical target regions was also interpreted visually using 3-dimensional stereotactic surface projections by three more and three less experienced readers. Spearman rank correlation coefficients were calculated between early-phase [18F]PI-2620 tau-PET and [18F]FDG-PET images for all cortical regions and frequencies of disagreement between images were compared for both more and less experienced readers.ResultsHighest agreement with [18F]FDG-PET quantification was reached for [18F]PI-2620-PET acquisition from 0.5 to 2.5 min p.i. for global mean (lowest R = 0.69) and cerebellar scaling (lowest R = 0.63). Correlation coefficients (summed 0.5–2.5 min SUVr & R1) displayed strong agreement in all cortical target regions for global mean (RSUVr 0.76, RR1 = 0.77) and cerebellar normalization (RSUVr 0.68, RR1 = 0.68). Visual interpretation revealed high regional correlations between early-phase tau-PET and [18F]FDG-PET. There were no relevant differences between more and less experienced readers.ConclusionEarly-phase imaging of [18F]PI-2620 can serve as a surrogate biomarker for neuronal injury. Dynamic imaging or a dual time-point protocol for tau-PET imaging could supersede additional [18F]FDG-PET imaging by indexing both the distribution of tau and the extent of neuronal injury.
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000875100 7001_ $$0P:(DE-HGF)0$$aBarthel, Henryk$$b2
000875100 7001_ $$0P:(DE-Juel1)169110$$avan Eimeren, Thilo$$b3
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000875100 7001_ $$0P:(DE-HGF)0$$aHerms, Jochen$$b26
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000875100 7001_ $$0P:(DE-HGF)0$$aLevin, Johannes$$b28
000875100 7001_ $$0P:(DE-HGF)0$$aClassen, Joseph$$b29
000875100 7001_ $$0P:(DE-HGF)0$$aHöglinger, Günter U.$$b30
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000875100 7001_ $$0P:(DE-HGF)0$$aBrendel, Matthias$$b36$$eCorresponding author
000875100 773__ $$0PERI:(DE-600)2098375-X$$a10.1007/s00259-020-04788-w$$p2911–2922$$tEuropean journal of nuclear medicine and molecular imaging$$v47$$x1619-7089$$y2020
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