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@ARTICLE{Beyer:875100,
      author       = {Beyer, Leonie and Nitschmann, Alexander and Barthel, Henryk
                      and van Eimeren, Thilo and Unterrainer, Marcus and
                      Sauerbeck, Julia and Marek, Ken and Song, Mengmeng and
                      Palleis, Carla and Respondek, Gesine and Hammes, Jochen and
                      Barbe, Michael T. and Onur, Özgür and Jessen, Frank and
                      Saur, Dorothee and Schroeter, Matthias L. and Rumpf,
                      Jost-Julian and Rullmann, Michael and Schildan, Andreas and
                      Patt, Marianne and Neumaier, Bernd and Barret, Olivier and
                      Madonia, Jennifer and Russell, David S. and Stephens, Andrew
                      W. and Roeber, Sigrun and Herms, Jochen and Bötzel, Kai and
                      Levin, Johannes and Classen, Joseph and Höglinger, Günter
                      U. and Bartenstein, Peter and Villemagne, Victor and
                      Drzezga, Alexander and Seibyl, John and Sabri, Osama and
                      Brendel, Matthias},
      title        = {{E}arly-phase [18{F}]{PI}-2620 tau-{PET} imaging as a
                      surrogate marker of neuronal injury},
      journal      = {European journal of nuclear medicine and molecular imaging},
      volume       = {47},
      issn         = {1619-7089},
      address      = {Heidelberg [u.a.]},
      publisher    = {Springer-Verl.},
      reportid     = {FZJ-2020-01803},
      pages        = {2911–2922},
      year         = {2020},
      abstract     = {PurposeSecond-generation tau radiotracers for use with
                      positron emission tomography (PET) have been developed for
                      visualization of tau deposits in vivo. For several
                      β-amyloid and first-generation tau-PET radiotracers, it has
                      been shown that early-phase images can be used as a
                      surrogate of neuronal injury. Therefore, we investigated the
                      performance of early acquisitions of the novel tau-PET
                      radiotracer [18F]PI-2620 as a potential substitute for
                      [18F]fluorodeoxyglucose ([18F]FDG).MethodsTwenty-six
                      subjects were referred with suspected tauopathies or
                      overlapping parkinsonian syndromes (Alzheimer’s disease,
                      progressive supranuclear palsy, corticobasal syndrome,
                      multi-system atrophy, Parkinson’s disease, multi-system
                      atrophy, Parkinson's disease, frontotemporal dementia) and
                      received a dynamic [18F]PI-2620 tau-PET (0–60 min p.i.)
                      and static [18F]FDG-PET (30–50 min p.i.). Regional
                      standardized uptake value ratios of early-phase images
                      (single frame SUVr) and the blood flow estimate (R1) of
                      [18F]PI-2620-PET were correlated with corresponding
                      quantification of [18F]FDG-PET (global mean/cerebellar
                      normalization). Reduced tracer uptake in cortical target
                      regions was also interpreted visually using 3-dimensional
                      stereotactic surface projections by three more and three
                      less experienced readers. Spearman rank correlation
                      coefficients were calculated between early-phase
                      [18F]PI-2620 tau-PET and [18F]FDG-PET images for all
                      cortical regions and frequencies of disagreement between
                      images were compared for both more and less experienced
                      readers.ResultsHighest agreement with [18F]FDG-PET
                      quantification was reached for [18F]PI-2620-PET acquisition
                      from 0.5 to 2.5 min p.i. for global mean (lowest R = 0.69)
                      and cerebellar scaling (lowest R = 0.63). Correlation
                      coefficients (summed 0.5–2.5 min SUVr $\&$ R1) displayed
                      strong agreement in all cortical target regions for global
                      mean (RSUVr 0.76, RR1 = 0.77) and cerebellar normalization
                      (RSUVr 0.68, RR1 = 0.68). Visual interpretation revealed
                      high regional correlations between early-phase tau-PET and
                      [18F]FDG-PET. There were no relevant differences between
                      more and less experienced readers.ConclusionEarly-phase
                      imaging of [18F]PI-2620 can serve as a surrogate biomarker
                      for neuronal injury. Dynamic imaging or a dual time-point
                      protocol for tau-PET imaging could supersede additional
                      [18F]FDG-PET imaging by indexing both the distribution of
                      tau and the extent of neuronal injury.},
      cin          = {INM-3 / INM-5 / INM-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406 / I:(DE-Juel1)INM-5-20090406 /
                      I:(DE-Juel1)INM-2-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32318783},
      UT           = {WOS:000528092500001},
      doi          = {10.1007/s00259-020-04788-w},
      url          = {https://juser.fz-juelich.de/record/875100},
}