000875133 001__ 875133
000875133 005__ 20210130004850.0
000875133 0247_ $$2doi$$a10.1002/hbm.25001
000875133 0247_ $$2ISSN$$a1065-9471
000875133 0247_ $$2ISSN$$a1097-0193
000875133 0247_ $$2Handle$$a2128/25252
000875133 0247_ $$2altmetric$$aaltmetric:80293560
000875133 0247_ $$2pmid$$apmid:32309893
000875133 0247_ $$2WOS$$aWOS:000527261100001
000875133 037__ $$aFZJ-2020-01826
000875133 082__ $$a610
000875133 1001_ $$0P:(DE-HGF)0$$aScharnowski, Frank$$b0$$eCorresponding author
000875133 245__ $$aThe role of the subgenual anterior cingulate cortex in dorsomedial prefrontal–amygdala neural circuitry during positive‐social emotion regulation
000875133 260__ $$aNew York, NY$$bWiley-Liss$$c2020
000875133 3367_ $$2DRIVER$$aarticle
000875133 3367_ $$2DataCite$$aOutput Types/Journal article
000875133 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1594213762_9935
000875133 3367_ $$2BibTeX$$aARTICLE
000875133 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000875133 3367_ $$00$$2EndNote$$aJournal Article
000875133 500__ $$aEuropean Research Council; European Union;Foundation for Research in Science, theHumanities at the University of Zurich, Grant/Award Number: STWF-17-012; BaugartenStiftung; Swiss National Science Foundation,Grant/Award Numbers: P300PB_161083,32003B_166566, 100014_178841,BSSG10_155915, PP00P2-146318, PZ00P3-131932This study was supported in part by the Center for Neuroscience of the University of Geneva, the Swiss National Science Foundation (FS: PZ00P3-131932, PP00P2-146318, BSSG10_155915, 100014_178841, 32003B_166566; YK: P300PB_161083), the Baugarten Stiftung, the Foundation for Research in Science, the Humanities at the University of Zurich (STWF-17-012) and the European Union. AN is also supported by the Marie Skłodowska-Curie individual fellowship from the European Research Commission. We thank Camille Piguet for helpful discussions. The authors do not have permission to share data. The authors declare no competing interests.
000875133 520__ $$aPositive-social emotions mediate one's cognitive performance, mood, well-being, and social bonds, and represent a critical variable within therapeutic settings. It has been shown that the upregulation of positive emotions in social situations is associated with increased top-down signals that stem from the prefrontal cortices (PFC) which modulate bottom-up emotional responses in the amygdala. However, it remains unclear if positive-social emotion upregulation of the amygdala occurs directly through the dorsomedial PFC (dmPFC) or indirectly linking the bilateral amygdala with the dmPFC via the subgenual anterior cingulate cortex (sgACC), an area which typically serves as a gatekeeper between cognitive and emotion networks. We performed functional MRI (fMRI) experiments with and without effortful positive-social emotion upregulation to demonstrate the functional architecture of a network involving the amygdala, the dmPFC, and the sgACC. We found that effortful positive-social emotion upregulation was associated with an increase in top-down connectivity from the dmPFC on the amygdala via both direct and indirect connections with the sgACC. Conversely, we found that emotion processes without effortful regulation increased network modulation by the sgACC and amygdala. We also found that more anxious individuals with a greater tendency to suppress emotions and intrusive thoughts, were likely to display decreased amygdala, dmPFC, and sgACC activity and stronger connectivity strength from the sgACC onto the left amygdala during effortful emotion upregulation. Analyzed brain network suggests a more general role of the sgACC in cognitive control and sheds light on neurobiological informed treatment interventions.
000875133 536__ $$0G:(DE-HGF)POF3-571$$a571 - Connectivity and Activity (POF3-571)$$cPOF3-571$$fPOF III$$x0
000875133 588__ $$aDataset connected to CrossRef
000875133 7001_ $$0P:(DE-HGF)0$$aNicholson, Andrew A.$$b1
000875133 7001_ $$0P:(DE-HGF)0$$aPichon, Swann$$b2
000875133 7001_ $$0P:(DE-HGF)0$$aRosa, Maria J.$$b3
000875133 7001_ $$0P:(DE-HGF)0$$aRey, Gwladys$$b4
000875133 7001_ $$0P:(DE-Juel1)131678$$aEickhoff, Simon B.$$b5
000875133 7001_ $$00000-0002-2879-3861$$aVan De Ville, Dimitri$$b6
000875133 7001_ $$0P:(DE-HGF)0$$aVuilleumier, Patrik$$b7
000875133 7001_ $$00000-0002-3684-5641$$aKoush, Yury$$b8$$eCorresponding author
000875133 773__ $$0PERI:(DE-600)1492703-2$$a10.1002/hbm.25001$$gp. hbm.25001$$n11$$p3100-3118$$tHuman brain mapping$$v41$$x1097-0193$$y2020
000875133 8564_ $$uhttps://juser.fz-juelich.de/record/875133/files/2020%20-%20HBM%20-%20Scharnowski_Koush%20-%20sgACC.pdf$$yOpenAccess$$zStatID:(DE-HGF)0510
000875133 8564_ $$uhttps://juser.fz-juelich.de/record/875133/files/2020%20-%20HBM%20-%20Scharnowski_Koush%20-%20sgACC.pdf?subformat=pdfa$$xpdfa$$yOpenAccess$$zStatID:(DE-HGF)0510
000875133 8564_ $$uhttps://juser.fz-juelich.de/record/875133/files/hbm.25001.pdf$$yRestricted$$zStatID:(DE-HGF)0599
000875133 8564_ $$uhttps://juser.fz-juelich.de/record/875133/files/hbm.25001.pdf?subformat=pdfa$$xpdfa$$yRestricted$$zStatID:(DE-HGF)0599
000875133 909CO $$ooai:juser.fz-juelich.de:875133$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000875133 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)131678$$aForschungszentrum Jülich$$b5$$kFZJ
000875133 9131_ $$0G:(DE-HGF)POF3-571$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vConnectivity and Activity$$x0
000875133 9141_ $$y2020
000875133 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000875133 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000875133 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bHUM BRAIN MAPP : 2017
000875133 915__ $$0LIC:(DE-HGF)CCBYNC4$$2HGFVOC$$aCreative Commons Attribution-NonCommercial CC BY-NC 4.0
000875133 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000875133 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000875133 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000875133 915__ $$0StatID:(DE-HGF)9900$$2StatID$$aIF < 5
000875133 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000875133 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000875133 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000875133 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000875133 915__ $$0StatID:(DE-HGF)0420$$2StatID$$aNationallizenz
000875133 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000875133 920__ $$lyes
000875133 9201_ $$0I:(DE-Juel1)INM-7-20090406$$kINM-7$$lGehirn & Verhalten$$x0
000875133 980__ $$ajournal
000875133 980__ $$aVDB
000875133 980__ $$aUNRESTRICTED
000875133 980__ $$aI:(DE-Juel1)INM-7-20090406
000875133 9801_ $$aFullTexts