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@ARTICLE{Scharnowski:875133,
      author       = {Scharnowski, Frank and Nicholson, Andrew A. and Pichon,
                      Swann and Rosa, Maria J. and Rey, Gwladys and Eickhoff,
                      Simon B. and Van De Ville, Dimitri and Vuilleumier, Patrik
                      and Koush, Yury},
      title        = {{T}he role of the subgenual anterior cingulate cortex in
                      dorsomedial prefrontal–amygdala neural circuitry during
                      positive‐social emotion regulation},
      journal      = {Human brain mapping},
      volume       = {41},
      number       = {11},
      issn         = {1097-0193},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2020-01826},
      pages        = {3100-3118},
      year         = {2020},
      note         = {European Research Council; European Union;Foundation for
                      Research in Science, theHumanities at the University of
                      Zurich, Grant/Award Number: STWF-17-012; BaugartenStiftung;
                      Swiss National Science Foundation,Grant/Award Numbers:
                      $P300PB_161083,32003B_166566,$
                      $100014_178841,BSSG10_155915,$ PP00P2-146318,
                      PZ00P3-131932This study was supported in part by the Center
                      for Neuroscience of the University of Geneva, the Swiss
                      National Science Foundation (FS: PZ00P3-131932,
                      PP00P2-146318, $BSSG10_155915,$ $100014_178841,$
                      $32003B_166566;$ YK: $P300PB_161083),$ the Baugarten
                      Stiftung, the Foundation for Research in Science, the
                      Humanities at the University of Zurich (STWF-17-012) and the
                      European Union. AN is also supported by the Marie
                      Skłodowska-Curie individual fellowship from the European
                      Research Commission. We thank Camille Piguet for helpful
                      discussions. The authors do not have permission to share
                      data. The authors declare no competing interests.},
      abstract     = {Positive-social emotions mediate one's cognitive
                      performance, mood, well-being, and social bonds, and
                      represent a critical variable within therapeutic settings.
                      It has been shown that the upregulation of positive emotions
                      in social situations is associated with increased top-down
                      signals that stem from the prefrontal cortices (PFC) which
                      modulate bottom-up emotional responses in the amygdala.
                      However, it remains unclear if positive-social emotion
                      upregulation of the amygdala occurs directly through the
                      dorsomedial PFC (dmPFC) or indirectly linking the bilateral
                      amygdala with the dmPFC via the subgenual anterior cingulate
                      cortex (sgACC), an area which typically serves as a
                      gatekeeper between cognitive and emotion networks. We
                      performed functional MRI (fMRI) experiments with and without
                      effortful positive-social emotion upregulation to
                      demonstrate the functional architecture of a network
                      involving the amygdala, the dmPFC, and the sgACC. We found
                      that effortful positive-social emotion upregulation was
                      associated with an increase in top-down connectivity from
                      the dmPFC on the amygdala via both direct and indirect
                      connections with the sgACC. Conversely, we found that
                      emotion processes without effortful regulation increased
                      network modulation by the sgACC and amygdala. We also found
                      that more anxious individuals with a greater tendency to
                      suppress emotions and intrusive thoughts, were likely to
                      display decreased amygdala, dmPFC, and sgACC activity and
                      stronger connectivity strength from the sgACC onto the left
                      amygdala during effortful emotion upregulation. Analyzed
                      brain network suggests a more general role of the sgACC in
                      cognitive control and sheds light on neurobiological
                      informed treatment interventions.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32309893},
      UT           = {WOS:000527261100001},
      doi          = {10.1002/hbm.25001},
      url          = {https://juser.fz-juelich.de/record/875133},
}