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@ARTICLE{Chase:875134,
      author       = {Chase, Henry W. and Grace, Anthony A. and Fox, Peter T. and
                      Phillips, Mary L. and Eickhoff, Simon B.},
      title        = {{F}unctional differentiation in the human ventromedial
                      frontal lobe: {A} data‐driven parcellation},
      journal      = {Human brain mapping},
      volume       = {41},
      number       = {12},
      issn         = {1097-0193},
      address      = {New York, NY},
      publisher    = {Wiley-Liss},
      reportid     = {FZJ-2020-01827},
      pages        = {3266–3283},
      year         = {2020},
      abstract     = {Ventromedial regions of the frontal lobe (vmFL) are thought
                      to play a key role in decision-making and emotional
                      regulation. However, aspects of this area's functional
                      organization, including the presence of a multiple
                      subregions, their functional and anatomical connectivity,
                      and the cross-species homologies of these subregions with
                      those of other species, remain poorly understood. To address
                      this uncertainty, we employed a two-stage parcellation of
                      the region to identify six distinct structures within the
                      region on the basis of data-driven classification of
                      functional connectivity patterns obtained using the
                      meta-analytic connectivity modeling (MACM) approach. From
                      anterior to posterior, the derived subregions included two
                      lateralized posterior regions, an intermediate posterior
                      region, a dorsal and ventral central region, and a single
                      anterior region. The regions were characterized further by
                      functional connectivity derived using resting-state fMRI and
                      functional decoding using the Brain Map database. In
                      general, the regions could be differentiated on the basis of
                      different patterns of functional connectivity with canonical
                      "default mode network" regions and/or subcortical regions
                      such as the striatum. Together, the findings suggest the
                      presence of functionally distinct neural structures within
                      vmFL, consistent with data from experimental animals as well
                      prior demonstrations of anatomical differences within the
                      region. Detailed correspondence with the anterior cingulate,
                      medial orbitofrontal cortex, and rostroventral prefrontal
                      cortex, as well as specific animal homologs are discussed.
                      The findings may suggest future directions for resolving
                      potential functional and structural correspondence of
                      subregions within the frontal lobe across behavioral
                      contexts, and across mammalian species.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32314470},
      UT           = {WOS:000527202000001},
      doi          = {10.1002/hbm.25014},
      url          = {https://juser.fz-juelich.de/record/875134},
}