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@ARTICLE{Baumer:875135,
      author       = {Baumer, Benedikt and Classen, Thomas and Pohl, Martina and
                      Pietruszka, Jörg},
      title        = {{E}fficient {N}icotinamide {A}denine {D}inucleotide
                      {P}hosphate [{NADP}({H})] {R}ecycling in {C}losed‐{L}oop
                      {C}ontinuous {F}low {B}iocatalysis},
      journal      = {Advanced synthesis $\&$ catalysis},
      volume       = {362},
      number       = {14},
      issn         = {1615-4169},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2020-01828},
      pages        = {2894-2901},
      year         = {2020},
      abstract     = {Biocatalytic redox reactions regularly depend on expensive
                      cofactors that require recycling. For continuous conversions
                      in flow chemistry, this is often an obstacle since the
                      cofactor is washed away. Here, we present a
                      quasi‐stationary recycling system for nicotinamide adenine
                      dinucleotide phosphate utilizing an immobilized alcohol
                      dehydrogenase. Four model substrates were reduced with high
                      enantioselectivity as a proof of concept. The two‐phase
                      system enables continuous production as well as quick
                      substrate changes. This setup may serve as a general
                      cofactor regeneration module for continuous biocatalytic
                      devices employing (co‐)substrates being miscible in
                      organic solvent. The system resulted in space‐time yields
                      up to 117 g L−1 h−1 and total turnover numbers for
                      nicotinamide adenine dinucleotide phosphate higher than
                      12,000 mol/mol are possible.},
      cin          = {IBG-1 / IBOC},
      ddc          = {660},
      cid          = {I:(DE-Juel1)IBG-1-20101118 / I:(DE-Juel1)IBOC-20090406},
      pnm          = {581 - Biotechnology (POF3-581)},
      pid          = {G:(DE-HGF)POF3-581},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000555591000012},
      doi          = {10.1002/adsc.202000058},
      url          = {https://juser.fz-juelich.de/record/875135},
}