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000875139 1001_ $$0P:(DE-Juel1)157953$$aMuschallik, Lukas$$b0
000875139 245__ $$aSynthesis of α-hydroxy ketones and vicinal ( R , R )-diols by Bacillus clausii DSM 8716 T butanediol dehydrogenase
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000875139 520__ $$aα-hydroxy ketones (HK) and 1,2-diols are important building blocks for fine chemical synthesis. Here, we describe the R-selective 2,3-butanediol dehydrogenase from B. clausii DSM 8716T (BcBDH) that belongs to the metal-dependent medium chain dehydrogenases/reductases family (MDR) and catalyzes the selective asymmetric reduction of prochiral 1,2-diketones to the corresponding HK and, in some cases, the reduction of the same to the corresponding 1,2-diols. Aliphatic diketones, like 2,3-pentanedione, 2,3-hexanedione, 5-methyl-2,3-hexanedione, 3,4-hexanedione and 2,3-heptanedione are well transformed. In addition, surprisingly alkyl phenyl dicarbonyls, like 2-hydroxy-1-phenylpropan-1-one and phenylglyoxal are accepted, whereas their derivatives with two phenyl groups are not substrates. Supplementation of Mn2+ (1 mM) increases BcBDH's activity in biotransformations. Furthermore, the biocatalytic reduction of 5-methyl-2,3-hexanedione to mainly 5-methyl-3-hydroxy-2-hexanone with only small amounts of 5-methyl-2-hydroxy-3-hexanone within an enzyme membrane reactor is demonstrated.
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000875139 7001_ $$0P:(DE-HGF)0$$aMolinnus, Denise$$b1
000875139 7001_ $$0P:(DE-HGF)0$$aJablonski, Melanie$$b2
000875139 7001_ $$0P:(DE-HGF)0$$aKipp, Carina Ronja$$b3
000875139 7001_ $$0P:(DE-HGF)0$$aBongaerts, Johannes$$b4
000875139 7001_ $$0P:(DE-Juel1)131522$$aPohl, Martina$$b5
000875139 7001_ $$0P:(DE-HGF)0$$aWagner, Torsten$$b6
000875139 7001_ $$0P:(DE-Juel1)128727$$aSchöning, Michael J.$$b7
000875139 7001_ $$0P:(DE-HGF)0$$aSelmer, Thorsten$$b8
000875139 7001_ $$0P:(DE-HGF)0$$aSiegert, Petra$$b9$$eCorresponding author
000875139 773__ $$0PERI:(DE-600)2623224-8$$a10.1039/D0RA02066D$$gVol. 10, no. 21, p. 12206 - 12216$$n21$$p12206 - 12216$$tRSC Advances$$v10$$x2046-2069$$y2020
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