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@ARTICLE{Muschallik:875139,
      author       = {Muschallik, Lukas and Molinnus, Denise and Jablonski,
                      Melanie and Kipp, Carina Ronja and Bongaerts, Johannes and
                      Pohl, Martina and Wagner, Torsten and Schöning, Michael J.
                      and Selmer, Thorsten and Siegert, Petra},
      title        = {{S}ynthesis of α-hydroxy ketones and vicinal ( {R} , {R}
                      )-diols by {B}acillus clausii {DSM} 8716 {T} butanediol
                      dehydrogenase},
      journal      = {RSC Advances},
      volume       = {10},
      number       = {21},
      issn         = {2046-2069},
      address      = {London},
      publisher    = {RSC Publishing},
      reportid     = {FZJ-2020-01831},
      pages        = {12206 - 12216},
      year         = {2020},
      abstract     = {α-hydroxy ketones (HK) and 1,2-diols are important
                      building blocks for fine chemical synthesis. Here, we
                      describe the R-selective 2,3-butanediol dehydrogenase from
                      B. clausii DSM 8716T (BcBDH) that belongs to the
                      metal-dependent medium chain dehydrogenases/reductases
                      family (MDR) and catalyzes the selective asymmetric
                      reduction of prochiral 1,2-diketones to the corresponding HK
                      and, in some cases, the reduction of the same to the
                      corresponding 1,2-diols. Aliphatic diketones, like
                      2,3-pentanedione, 2,3-hexanedione, 5-methyl-2,3-hexanedione,
                      3,4-hexanedione and 2,3-heptanedione are well transformed.
                      In addition, surprisingly alkyl phenyl dicarbonyls, like
                      2-hydroxy-1-phenylpropan-1-one and phenylglyoxal are
                      accepted, whereas their derivatives with two phenyl groups
                      are not substrates. Supplementation of Mn2+ (1 mM) increases
                      BcBDH's activity in biotransformations. Furthermore, the
                      biocatalytic reduction of 5-methyl-2,3-hexanedione to mainly
                      5-methyl-3-hydroxy-2-hexanone with only small amounts of
                      5-methyl-2-hydroxy-3-hexanone within an enzyme membrane
                      reactor is demonstrated.},
      cin          = {IBG-1},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {581 - Biotechnology (POF3-581)},
      pid          = {G:(DE-HGF)POF3-581},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000526839700010},
      doi          = {10.1039/D0RA02066D},
      url          = {https://juser.fz-juelich.de/record/875139},
}