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| Home > Publications database > Synthesis of α-hydroxy ketones and vicinal ( R , R )-diols by Bacillus clausii DSM 8716 T butanediol dehydrogenase > print |
| Home > Publications database > Synthesis of α-hydroxy ketones and vicinal ( R , R )-diols by Bacillus clausii DSM 8716 T butanediol dehydrogenase > print |
| 001 | 875139 | ||
| 005 | 20210130004851.0 | ||
| 024 | 7 | _ | |a 10.1039/D0RA02066D |2 doi |
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| 100 | 1 | _ | |a Muschallik, Lukas |0 P:(DE-Juel1)157953 |b 0 |
| 245 | _ | _ | |a Synthesis of α-hydroxy ketones and vicinal ( R , R )-diols by Bacillus clausii DSM 8716 T butanediol dehydrogenase |
| 260 | _ | _ | |a London |c 2020 |b RSC Publishing |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 520 | _ | _ | |a α-hydroxy ketones (HK) and 1,2-diols are important building blocks for fine chemical synthesis. Here, we describe the R-selective 2,3-butanediol dehydrogenase from B. clausii DSM 8716T (BcBDH) that belongs to the metal-dependent medium chain dehydrogenases/reductases family (MDR) and catalyzes the selective asymmetric reduction of prochiral 1,2-diketones to the corresponding HK and, in some cases, the reduction of the same to the corresponding 1,2-diols. Aliphatic diketones, like 2,3-pentanedione, 2,3-hexanedione, 5-methyl-2,3-hexanedione, 3,4-hexanedione and 2,3-heptanedione are well transformed. In addition, surprisingly alkyl phenyl dicarbonyls, like 2-hydroxy-1-phenylpropan-1-one and phenylglyoxal are accepted, whereas their derivatives with two phenyl groups are not substrates. Supplementation of Mn2+ (1 mM) increases BcBDH's activity in biotransformations. Furthermore, the biocatalytic reduction of 5-methyl-2,3-hexanedione to mainly 5-methyl-3-hydroxy-2-hexanone with only small amounts of 5-methyl-2-hydroxy-3-hexanone within an enzyme membrane reactor is demonstrated. |
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| 700 | 1 | _ | |a Molinnus, Denise |0 P:(DE-HGF)0 |b 1 |
| 700 | 1 | _ | |a Jablonski, Melanie |0 P:(DE-HGF)0 |b 2 |
| 700 | 1 | _ | |a Kipp, Carina Ronja |0 P:(DE-HGF)0 |b 3 |
| 700 | 1 | _ | |a Bongaerts, Johannes |0 P:(DE-HGF)0 |b 4 |
| 700 | 1 | _ | |a Pohl, Martina |0 P:(DE-Juel1)131522 |b 5 |
| 700 | 1 | _ | |a Wagner, Torsten |0 P:(DE-HGF)0 |b 6 |
| 700 | 1 | _ | |a Schöning, Michael J. |0 P:(DE-Juel1)128727 |b 7 |
| 700 | 1 | _ | |a Selmer, Thorsten |0 P:(DE-HGF)0 |b 8 |
| 700 | 1 | _ | |a Siegert, Petra |0 P:(DE-HGF)0 |b 9 |e Corresponding author |
| 773 | _ | _ | |a 10.1039/D0RA02066D |g Vol. 10, no. 21, p. 12206 - 12216 |0 PERI:(DE-600)2623224-8 |n 21 |p 12206 - 12216 |t RSC Advances |v 10 |y 2020 |x 2046-2069 |
| 856 | 4 | _ | |y OpenAccess |u https://juser.fz-juelich.de/record/875139/files/d0ra02066d.pdf |
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