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@ARTICLE{Milke:875240,
      author       = {Milke, Lars and Marienhagen, Jan},
      title        = {{E}ngineering intracellular malonyl-{C}o{A} availability in
                      microbial hosts and its impact on polyketide and fatty acid
                      synthesis},
      journal      = {Applied microbiology and biotechnology},
      volume       = {104},
      issn         = {0171-1741},
      address      = {New York},
      publisher    = {Springer},
      reportid     = {FZJ-2020-01889},
      pages        = {6057–6065},
      year         = {2020},
      note         = {Biotechnologie 1},
      abstract     = {Malonyl-CoA is an important central metabolite serving as
                      the basic building block for the microbial synthesis of many
                      pharmaceutically interesting polyketides, but also fatty
                      acid–derived compounds including biofuels. Especially
                      Saccharomyces cerevisiae, Escherichia coli, and
                      Corynebacterium glutamicum have been engineered towards
                      microbial synthesis of such compounds in recent years.
                      However, developed strains and processes often suffer from
                      insufficient productivity. Usually, tightly regulated
                      intracellular malonyl-CoA availability is regarded as the
                      decisive bottleneck limiting overall product formation.
                      Therefore, metabolic engineering towards improved
                      malonyl-CoA availability is essential to design efficient
                      microbial cell factories for the production of polyketides
                      and fatty acid derivatives. This review article summarizes
                      metabolic engineering strategies to improve intracellular
                      malonyl-CoA formation in industrially relevant
                      microorganisms and its impact on productivity and product
                      range, with a focus on polyketides and other
                      malonyl-CoA-dependent products.},
      cin          = {IBG-1},
      ddc          = {570},
      cid          = {I:(DE-Juel1)IBG-1-20101118},
      pnm          = {583 - Innovative Synergisms (POF3-583)},
      pid          = {G:(DE-HGF)POF3-583},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32385515},
      UT           = {WOS:000531119300001},
      doi          = {10.1007/s00253-020-10643-7},
      url          = {https://juser.fz-juelich.de/record/875240},
}