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@ARTICLE{Minol:875339,
      author       = {Minol, Jan-Philipp and Dimitrova, Vanessa and Petrov,
                      Georgi and Langner, Robert and Boeken, Udo and Rellecke,
                      Philipp and Aubin, Hug and Kamiya, Hiroyuki and Sixt,
                      Stephan and Huhn, Ragnar and Sugimura, Yukiharu and Albert,
                      Alexander and Lichtenberg, Artur and Akhyari, Payam},
      title        = {{T}he age-adjusted {C}harlson comorbidity index in
                      minimally invasive mitral valve surgery},
      journal      = {European journal of cardio-thoracic surgery},
      volume       = {56},
      number       = {6},
      issn         = {1873-734X},
      address      = {Oxford},
      publisher    = {Oxford Univ. Press},
      reportid     = {FZJ-2020-01962},
      pages        = {1124 - 1130},
      year         = {2019},
      abstract     = {OBJECTIVESMitral valve repair is the preferred method used
                      to address mitral valve regurgitation, whereas transcatheter
                      mitral valve repair is recommended for high-risk patients.
                      We evaluated the risk-predictive value of the age-adjusted
                      Charlson comorbidity index (aa-CCI) in the setting of
                      minimally invasive mitral valve surgery.METHODSThe
                      perioperative course and 1-year follow-up of 537 patients
                      who underwent isolated or combined minimally invasive mitral
                      valve surgery were evaluated for 1-year mortality as the
                      primary end point and other adverse events. The predictive
                      values of the EuroSCORE II and STS score were compared to
                      that of the aa-CCI by a comparative analysis of receiver
                      operating characteristic curves. Restricted cubic splines
                      were applied to find optimal aa-CCI cut-off values for the
                      increased likelihood of experiencing the predefined adverse
                      end points. Consequently, the perioperative course and
                      postoperative outcome of the aa-CCI ≥8 patients and the
                      remainder of the sample were analysed.RESULTSThe predictive
                      value of the aa-CCI does not significantly differ from those
                      of the EuroSCORE II or STS score. Patients with an aa-CCI
                      ≥8 were identified as a subgroup with a significant
                      increase of mortality and other adverse
                      events.CONCLUSIONSThe aa-CCI displays a suitable predictive
                      ability for patients undergoing minimally invasive mitral
                      valve surgery. In particular, multimorbid or frail patients
                      may benefit from the extension of the objectively assessed
                      parameters, in addition to the STS score or EuroSCORE II.
                      Patients with an aa-CCI ≥8 have a very high surgical risk
                      and should receive very careful attention.},
      cin          = {INM-7},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-7-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:31501891},
      UT           = {WOS:000501730300014},
      doi          = {10.1093/ejcts/ezz240},
      url          = {https://juser.fz-juelich.de/record/875339},
}