%0 Journal Article
%A Jost, Stefanie Theresa
%A Sauerbier, Anna
%A Visser-Vandewalle, Veerle
%A Ashkan, Keyoumars
%A Silverdale, Monty
%A Evans, Julian
%A Loehrer, Philipp A
%A Rizos, Alexandra
%A Petry-Schmelzer, Jan Niklas
%A Reker, Paul
%A Fink, Gereon Rudolf
%A Franklin, Jeremy
%A Samuel, Michael
%A Schnitzler, Alfons
%A Barbe, Michael Thomas
%A Antonini, Angelo
%A Martinez-Martin, Pablo
%A Timmermann, Lars
%A Ray-Chaudhuri, K.
%A Dafsari, Haidar S
%T A prospective, controlled study of non-motor effects of subthalamic stimulation in Parkinson’s disease: results at the 36-month follow-up
%J Journal of neurology, neurosurgery, and psychiatry
%V 91
%N 7
%@ 1468-330X
%C London
%I BMJ Publishing Group
%M FZJ-2020-01988
%P 687-694
%D 2020
%X Objective To examine 36-month effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on non-motor symptoms (NMS) compared with standard-of-care medical treatment (MED) in Parkinson’s disease (PD).Methods Here we report the 36-month follow-up of a prospective, observational, controlled, international multicentre study of the NILS cohort. Assessments included NMSScale (NMSS), PDQuestionnaire-8 (PDQ-8), Scales for Outcomes in PD (SCOPA)-motor examination, -activities of daily living, and -complications, and levodopa equivalent daily dose (LEDD). Propensity score matching resulted in a pseudo-randomised sub-cohort balancing baseline demographic and clinical characteristics between the STN-DBS and MED groups. Within-group longitudinal outcome changes were analysed using Wilcoxon signed-rank and between-group differences of change scores with Mann-Whitney U test. Strength of clinical responses was quantified with Cohen’s effect size. In addition, bivariate correlations of change scores were explored.Results Propensity score matching applied on the cohort of 151 patients (STN-DBS n=67, MED n=84) resulted in a well-balanced sub-cohort including 38 patients per group. After 36 months, STN-DBS significantly improved NMSS, PDQ-8, SCOPA-motor examination and -complications and reduced LEDD. Significant between-group differences, all favouring STN-DBS, were found for NMSS, SCOPA-motor complications, LEDD (large effects), motor examination and PDQ-8 (moderate effects). Furthermore, significant differences were found for the sleep/fatigue, urinary (large effects) and miscellaneous NMSS domains (moderate effects). NMSS total and PDQ-8 change scores correlated significantly.Conclusions This study provides Class IIb evidence for beneficial effects of STN-DBS on NMS at 36-month follow-up which also correlated with quality of life improvements. This highlights the importance of NMS for DBS outcomes assessments.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32371534
%U <Go to ISI:>//WOS:000545962100005
%R 10.1136/jnnp-2019-322614
%U https://juser.fz-juelich.de/record/875374