TY  - JOUR
AU  - Jost, Stefanie Theresa
AU  - Sauerbier, Anna
AU  - Visser-Vandewalle, Veerle
AU  - Ashkan, Keyoumars
AU  - Silverdale, Monty
AU  - Evans, Julian
AU  - Loehrer, Philipp A
AU  - Rizos, Alexandra
AU  - Petry-Schmelzer, Jan Niklas
AU  - Reker, Paul
AU  - Fink, Gereon Rudolf
AU  - Franklin, Jeremy
AU  - Samuel, Michael
AU  - Schnitzler, Alfons
AU  - Barbe, Michael Thomas
AU  - Antonini, Angelo
AU  - Martinez-Martin, Pablo
AU  - Timmermann, Lars
AU  - Ray-Chaudhuri, K.
AU  - Dafsari, Haidar S
TI  - A prospective, controlled study of non-motor effects of subthalamic stimulation in Parkinson’s disease: results at the 36-month follow-up
JO  - Journal of neurology, neurosurgery, and psychiatry
VL  - 91
IS  - 7
SN  - 1468-330X
CY  - London
PB  - BMJ Publishing Group
M1  - FZJ-2020-01988
SP  - 687-694
PY  - 2020
AB  - Objective To examine 36-month effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on non-motor symptoms (NMS) compared with standard-of-care medical treatment (MED) in Parkinson’s disease (PD).Methods Here we report the 36-month follow-up of a prospective, observational, controlled, international multicentre study of the NILS cohort. Assessments included NMSScale (NMSS), PDQuestionnaire-8 (PDQ-8), Scales for Outcomes in PD (SCOPA)-motor examination, -activities of daily living, and -complications, and levodopa equivalent daily dose (LEDD). Propensity score matching resulted in a pseudo-randomised sub-cohort balancing baseline demographic and clinical characteristics between the STN-DBS and MED groups. Within-group longitudinal outcome changes were analysed using Wilcoxon signed-rank and between-group differences of change scores with Mann-Whitney U test. Strength of clinical responses was quantified with Cohen’s effect size. In addition, bivariate correlations of change scores were explored.Results Propensity score matching applied on the cohort of 151 patients (STN-DBS n=67, MED n=84) resulted in a well-balanced sub-cohort including 38 patients per group. After 36 months, STN-DBS significantly improved NMSS, PDQ-8, SCOPA-motor examination and -complications and reduced LEDD. Significant between-group differences, all favouring STN-DBS, were found for NMSS, SCOPA-motor complications, LEDD (large effects), motor examination and PDQ-8 (moderate effects). Furthermore, significant differences were found for the sleep/fatigue, urinary (large effects) and miscellaneous NMSS domains (moderate effects). NMSS total and PDQ-8 change scores correlated significantly.Conclusions This study provides Class IIb evidence for beneficial effects of STN-DBS on NMS at 36-month follow-up which also correlated with quality of life improvements. This highlights the importance of NMS for DBS outcomes assessments.
LB  - PUB:(DE-HGF)16
C6  - pmid:32371534
UR  - <Go to ISI:>//WOS:000545962100005
DO  - DOI:10.1136/jnnp-2019-322614
UR  - https://juser.fz-juelich.de/record/875374
ER  -