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@ARTICLE{Jost:875374,
      author       = {Jost, Stefanie Theresa and Sauerbier, Anna and
                      Visser-Vandewalle, Veerle and Ashkan, Keyoumars and
                      Silverdale, Monty and Evans, Julian and Loehrer, Philipp A
                      and Rizos, Alexandra and Petry-Schmelzer, Jan Niklas and
                      Reker, Paul and Fink, Gereon Rudolf and Franklin, Jeremy and
                      Samuel, Michael and Schnitzler, Alfons and Barbe, Michael
                      Thomas and Antonini, Angelo and Martinez-Martin, Pablo and
                      Timmermann, Lars and Ray-Chaudhuri, K. and Dafsari, Haidar
                      S},
      title        = {{A} prospective, controlled study of non-motor effects of
                      subthalamic stimulation in {P}arkinson’s disease: results
                      at the 36-month follow-up},
      journal      = {Journal of neurology, neurosurgery, and psychiatry},
      volume       = {91},
      number       = {7},
      issn         = {1468-330X},
      address      = {London},
      publisher    = {BMJ Publishing Group},
      reportid     = {FZJ-2020-01988},
      pages        = {687-694},
      year         = {2020},
      abstract     = {Objective To examine 36-month effects of bilateral
                      subthalamic nucleus deep brain stimulation (STN-DBS) on
                      non-motor symptoms (NMS) compared with standard-of-care
                      medical treatment (MED) in Parkinson’s disease
                      (PD).Methods Here we report the 36-month follow-up of a
                      prospective, observational, controlled, international
                      multicentre study of the NILS cohort. Assessments included
                      NMSScale (NMSS), PDQuestionnaire-8 (PDQ-8), Scales for
                      Outcomes in PD (SCOPA)-motor examination, -activities of
                      daily living, and -complications, and levodopa equivalent
                      daily dose (LEDD). Propensity score matching resulted in a
                      pseudo-randomised sub-cohort balancing baseline demographic
                      and clinical characteristics between the STN-DBS and MED
                      groups. Within-group longitudinal outcome changes were
                      analysed using Wilcoxon signed-rank and between-group
                      differences of change scores with Mann-Whitney U test.
                      Strength of clinical responses was quantified with Cohen’s
                      effect size. In addition, bivariate correlations of change
                      scores were explored.Results Propensity score matching
                      applied on the cohort of 151 patients (STN-DBS n=67, MED
                      n=84) resulted in a well-balanced sub-cohort including 38
                      patients per group. After 36 months, STN-DBS significantly
                      improved NMSS, PDQ-8, SCOPA-motor examination and
                      -complications and reduced LEDD. Significant between-group
                      differences, all favouring STN-DBS, were found for NMSS,
                      SCOPA-motor complications, LEDD (large effects), motor
                      examination and PDQ-8 (moderate effects). Furthermore,
                      significant differences were found for the sleep/fatigue,
                      urinary (large effects) and miscellaneous NMSS domains
                      (moderate effects). NMSS total and PDQ-8 change scores
                      correlated significantly.Conclusions This study provides
                      Class IIb evidence for beneficial effects of STN-DBS on NMS
                      at 36-month follow-up which also correlated with quality of
                      life improvements. This highlights the importance of NMS for
                      DBS outcomes assessments.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32371534},
      UT           = {WOS:000545962100005},
      doi          = {10.1136/jnnp-2019-322614},
      url          = {https://juser.fz-juelich.de/record/875374},
}