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| 001 | 875374 | ||
| 005 | 20210130004924.0 | ||
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| 100 | 1 | _ | |a Jost, Stefanie Theresa |0 0000-0003-0477-2289 |b 0 |e Corresponding author |
| 245 | _ | _ | |a A prospective, controlled study of non-motor effects of subthalamic stimulation in Parkinson’s disease: results at the 36-month follow-up |
| 260 | _ | _ | |a London |c 2020 |b BMJ Publishing Group |
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| 520 | _ | _ | |a Objective To examine 36-month effects of bilateral subthalamic nucleus deep brain stimulation (STN-DBS) on non-motor symptoms (NMS) compared with standard-of-care medical treatment (MED) in Parkinson’s disease (PD).Methods Here we report the 36-month follow-up of a prospective, observational, controlled, international multicentre study of the NILS cohort. Assessments included NMSScale (NMSS), PDQuestionnaire-8 (PDQ-8), Scales for Outcomes in PD (SCOPA)-motor examination, -activities of daily living, and -complications, and levodopa equivalent daily dose (LEDD). Propensity score matching resulted in a pseudo-randomised sub-cohort balancing baseline demographic and clinical characteristics between the STN-DBS and MED groups. Within-group longitudinal outcome changes were analysed using Wilcoxon signed-rank and between-group differences of change scores with Mann-Whitney U test. Strength of clinical responses was quantified with Cohen’s effect size. In addition, bivariate correlations of change scores were explored.Results Propensity score matching applied on the cohort of 151 patients (STN-DBS n=67, MED n=84) resulted in a well-balanced sub-cohort including 38 patients per group. After 36 months, STN-DBS significantly improved NMSS, PDQ-8, SCOPA-motor examination and -complications and reduced LEDD. Significant between-group differences, all favouring STN-DBS, were found for NMSS, SCOPA-motor complications, LEDD (large effects), motor examination and PDQ-8 (moderate effects). Furthermore, significant differences were found for the sleep/fatigue, urinary (large effects) and miscellaneous NMSS domains (moderate effects). NMSS total and PDQ-8 change scores correlated significantly.Conclusions This study provides Class IIb evidence for beneficial effects of STN-DBS on NMS at 36-month follow-up which also correlated with quality of life improvements. This highlights the importance of NMS for DBS outcomes assessments. |
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| 700 | 1 | _ | |a Dafsari, Haidar S |0 0000-0001-8849-4233 |b 19 |e Corresponding author |
| 773 | _ | _ | |a 10.1136/jnnp-2019-322614 |g p. jnnp-2019-322614 - |0 PERI:(DE-600)1480429-3 |n 7 |p 687-694 |t Journal of neurology, neurosurgery, and psychiatry |v 91 |y 2020 |x 1468-330X |
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