000875382 001__ 875382
000875382 005__ 20210130004925.0
000875382 0247_ $$2doi$$a10.1038/s41467-020-16022-0
000875382 0247_ $$2pmid$$apmid:32385265
000875382 0247_ $$2Handle$$a2128/24879
000875382 0247_ $$2altmetric$$aaltmetric:81643270
000875382 0247_ $$2WOS$$aWOS:000533936800025
000875382 037__ $$aFZJ-2020-01993
000875382 041__ $$aeng
000875382 082__ $$a500
000875382 1001_ $$00000-0002-0538-4774$$aShen, Xueyi$$b0
000875382 245__ $$aA phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank.
000875382 260__ $$a[London]$$bNature Publishing Group UK$$c2020
000875382 3367_ $$2DRIVER$$aarticle
000875382 3367_ $$2DataCite$$aOutput Types/Journal article
000875382 3367_ $$0PUB:(DE-HGF)16$$2PUB:(DE-HGF)$$aJournal Article$$bjournal$$mjournal$$s1589456462_11909
000875382 3367_ $$2BibTeX$$aARTICLE
000875382 3367_ $$2ORCID$$aJOURNAL_ARTICLE
000875382 3367_ $$00$$2EndNote$$aJournal Article
000875382 520__ $$aDepression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in a discovery (N = 10,674) and replication (N = 11,214) imaging sample from UK Biobank. We report 77 traits that are significantly associated with depression-PRS, in both discovery and replication analyses. Mendelian Randomisation analysis supports a potential causal effect of liability to depression on brain white matter microstructure (β: 0.125 to 0.868, pFDR < 0.043). Several behavioural traits are also associated with depression-PRS (β: 0.014 to 0.180, pFDR: 0.049 to 1.28 × 10-14) and we find a significant and positive interaction between depression-PRS and adverse environmental exposures on mental health outcomes. This study reveals replicable associations between depression-PRS and white matter microstructure. Our results indicate that white matter microstructure differences may be a causal consequence of liability to depression.
000875382 536__ $$0G:(DE-HGF)POF3-571$$a571 - Connectivity and Activity (POF3-571)$$cPOF3-571$$fPOF III$$x0
000875382 588__ $$aDataset connected to CrossRef, PubMed,
000875382 7001_ $$00000-0002-6005-1972$$aHoward, David M$$b1
000875382 7001_ $$00000-0002-3599-6018$$aAdams, Mark J$$b2
000875382 7001_ $$0P:(DE-HGF)0$$aHill, W David$$b3
000875382 7001_ $$0P:(DE-HGF)0$$aClarke, Toni-Kim$$b4
000875382 7001_ $$0P:(DE-HGF)0$$aDeary, Ian J$$b5
000875382 7001_ $$00000-0002-4505-8869$$aWhalley, Heather C$$b6
000875382 7001_ $$00000-0002-0198-4588$$aMcIntosh, Andrew M$$b7$$eCorresponding author
000875382 7001_ $$aAdams, Mark J$$b8
000875382 7001_ $$aClarke, Toni-Kim$$b9
000875382 7001_ $$aMcIntosh, Andrew M$$b10
000875382 7001_ $$aDeary, Ian J$$b11
000875382 7001_ $$aWray, Naomi R$$b12
000875382 7001_ $$aRipke, Stephan$$b13
000875382 7001_ $$aMattheisen, Manuel$$b14
000875382 7001_ $$aTrzaskowski, Maciej$$b15
000875382 7001_ $$aByrne, Enda M$$b16
000875382 7001_ $$aAbdellaoui, Abdel$$b17
000875382 7001_ $$aAgerbo, Esben$$b18
000875382 7001_ $$aAir, Tracy M$$b19
000875382 7001_ $$aAndlauer, Till F M$$b20
000875382 7001_ $$aBacanu, Silviu-Alin$$b21
000875382 7001_ $$aBækvad-Hansen, Marie$$b22
000875382 7001_ $$aBeekman, Aartjan T F$$b23
000875382 7001_ $$aBigdeli, Tim B$$b24
000875382 7001_ $$aBinder, Elisabeth B$$b25
000875382 7001_ $$aBryois, Julien$$b26
000875382 7001_ $$aButtenschøn, Henriette N$$b27
000875382 7001_ $$aBybjerg-Grauholm, Jonas$$b28
000875382 7001_ $$aCai, Na$$b29
000875382 7001_ $$aCastelao, Enrique$$b30
000875382 7001_ $$aChristensen, Jane Hvarregaard$$b31
000875382 7001_ $$aColeman, Jonathan R I$$b32
000875382 7001_ $$aColodro-Conde, Lucía$$b33
000875382 7001_ $$aCouvy-Duchesne, Baptiste$$b34
000875382 7001_ $$aCraddock, Nick$$b35
000875382 7001_ $$aCrawford, Gregory E$$b36
000875382 7001_ $$aDavies, Gail$$b37
000875382 7001_ $$aDegenhardt, Franziska$$b38
000875382 7001_ $$aDerks, Eske M$$b39
000875382 7001_ $$aDirek, Nese$$b40
000875382 7001_ $$aDolan, Conor V$$b41
000875382 7001_ $$aDunn, Erin C$$b42
000875382 7001_ $$aEley, Thalia C$$b43
000875382 7001_ $$aEscott-Price, Valentina$$b44
000875382 7001_ $$aKiadeh, Farnush Farhadi Hassan$$b45
000875382 7001_ $$aFinucane, Hilary K$$b46
000875382 7001_ $$aFoo, Jerome C$$b47
000875382 7001_ $$aForstner, Andreas J$$b48
000875382 7001_ $$aFrank, Josef$$b49
000875382 7001_ $$aGaspar, Héléna A$$b50
000875382 7001_ $$aGill, Michael$$b51
000875382 7001_ $$aGoes, Fernando S$$b52
000875382 7001_ $$aGordon, Scott D$$b53
000875382 7001_ $$aGrove, Jakob$$b54
000875382 7001_ $$aHall, Lynsey S$$b55
000875382 7001_ $$aHansen, Christine Søholm$$b56
000875382 7001_ $$aHansen, Thomas F$$b57
000875382 7001_ $$aHerms, Stefan$$b58
000875382 7001_ $$aHickie, Ian B$$b59
000875382 7001_ $$aHoffmann, Per$$b60
000875382 7001_ $$aHomuth, Georg$$b61
000875382 7001_ $$aHorn, Carsten$$b62
000875382 7001_ $$aHottenga, Jouke-Jan$$b63
000875382 7001_ $$aHougaard, David M$$b64
000875382 7001_ $$aHoward, David M$$b65
000875382 7001_ $$aIsing, Marcus$$b66
000875382 7001_ $$aJansen, Rick$$b67
000875382 7001_ $$aJones, Ian$$b68
000875382 7001_ $$aJones, Lisa A$$b69
000875382 7001_ $$aJorgenson, Eric$$b70
000875382 7001_ $$aKnowles, James A$$b71
000875382 7001_ $$aKohane, Isaac S$$b72
000875382 7001_ $$aKraft, Julia$$b73
000875382 7001_ $$aKretzschmar, Warren W$$b74
000875382 7001_ $$aKutalik, Zoltán$$b75
000875382 7001_ $$aLi, Yihan$$b76
000875382 7001_ $$aLind, Penelope A$$b77
000875382 7001_ $$aMacIntyre, Donald J$$b78
000875382 7001_ $$aMacKinnon, Dean F$$b79
000875382 7001_ $$aMaier, Robert M$$b80
000875382 7001_ $$aMaier, Wolfgang$$b81
000875382 7001_ $$aMarchini, Jonathan$$b82
000875382 7001_ $$aMbarek, Hamdi$$b83
000875382 7001_ $$aMcGrath, Patrick$$b84
000875382 7001_ $$aMcGuffin, Peter$$b85
000875382 7001_ $$aMedland, Sarah E$$b86
000875382 7001_ $$aMehta, Divya$$b87
000875382 7001_ $$aMiddeldorp, Christel M$$b88
000875382 7001_ $$aMihailov, Evelin$$b89
000875382 7001_ $$aMilaneschi, Yuri$$b90
000875382 7001_ $$aMilani, Lili$$b91
000875382 7001_ $$aMondimore, Francis M$$b92
000875382 7001_ $$aMontgomery, Grant W$$b93
000875382 7001_ $$aMostafavi, Sara$$b94
000875382 7001_ $$aMullins, Niamh$$b95
000875382 7001_ $$aNauck, Matthias$$b96
000875382 7001_ $$aNg, Bernard$$b97
000875382 7001_ $$aNivard, Michel G$$b98
000875382 7001_ $$aNyholt, Dale R$$b99
000875382 7001_ $$aO'Reilly, Paul F$$b100
000875382 7001_ $$aOskarsson, Hogni$$b101
000875382 7001_ $$aOwen, Michael J$$b102
000875382 7001_ $$aPainter, Jodie N$$b103
000875382 7001_ $$aPedersen, Carsten Bøcker$$b104
000875382 7001_ $$aPedersen, Marianne Giørtz$$b105
000875382 7001_ $$aPeterson, Roseann E$$b106
000875382 7001_ $$aPettersson, Erik$$b107
000875382 7001_ $$aPeyrot, Wouter J$$b108
000875382 7001_ $$aPistis, Giorgio$$b109
000875382 7001_ $$aPosthuma, Danielle$$b110
000875382 7001_ $$aQuiroz, Jorge A$$b111
000875382 7001_ $$aQvist, Per$$b112
000875382 7001_ $$aRice, John P$$b113
000875382 7001_ $$aRiley, Brien P$$b114
000875382 7001_ $$aRivera, Margarita$$b115
000875382 7001_ $$aMirza, Saira Saeed$$b116
000875382 7001_ $$aSchoevers, Robert$$b117
000875382 7001_ $$aSchulte, Eva C$$b118
000875382 7001_ $$aShen, Ling$$b119
000875382 7001_ $$aShi, Jianxin$$b120
000875382 7001_ $$aShyn, Stanley I$$b121
000875382 7001_ $$aSigurdsson, Engilbert$$b122
000875382 7001_ $$aSinnamon, Grant C B$$b123
000875382 7001_ $$aSmit, Johannes H$$b124
000875382 7001_ $$aSmith, Daniel J$$b125
000875382 7001_ $$aStefansson, Hreinn$$b126
000875382 7001_ $$aSteinberg, Stacy$$b127
000875382 7001_ $$aStreit, Fabian$$b128
000875382 7001_ $$aStrohmaier, Jana$$b129
000875382 7001_ $$aTansey, Katherine E$$b130
000875382 7001_ $$aTeismann, Henning$$b131
000875382 7001_ $$aTeumer, Alexander$$b132
000875382 7001_ $$aThompson, Wesley$$b133
000875382 7001_ $$aThomson, Pippa A$$b134
000875382 7001_ $$aThorgeirsson, Thorgeir E$$b135
000875382 7001_ $$aTraylor, Matthew$$b136
000875382 7001_ $$aTreutlein, Jens$$b137
000875382 7001_ $$aTrubetskoy, Vassily$$b138
000875382 7001_ $$aUitterlinden, Andrés G$$b139
000875382 7001_ $$aUmbricht, Daniel$$b140
000875382 7001_ $$aAuwera, Sandra Van der$$b141
000875382 7001_ $$avan Hemert, Albert M$$b142
000875382 7001_ $$aViktorin, Alexander$$b143
000875382 7001_ $$aVisscher, Peter M$$b144
000875382 7001_ $$aWang, Yunpeng$$b145
000875382 7001_ $$aWebb, Bradley T$$b146
000875382 7001_ $$aWeinsheimer, Shantel Marie$$b147
000875382 7001_ $$aWellmann, Jürgen$$b148
000875382 7001_ $$aWillemsen, Gonneke$$b149
000875382 7001_ $$aWitt, Stephanie H$$b150
000875382 7001_ $$aWu, Yang$$b151
000875382 7001_ $$aXi, Hualin S$$b152
000875382 7001_ $$aYang, Jian$$b153
000875382 7001_ $$aZhang, Futao$$b154
000875382 7001_ $$aArolt, Volker$$b155
000875382 7001_ $$aBaune, Bernhard T$$b156
000875382 7001_ $$aBerger, Klaus$$b157
000875382 7001_ $$aBoomsma, Dorret I$$b158
000875382 7001_ $$0P:(DE-Juel1)140234$$aCichon, Sven$$b159
000875382 7001_ $$aDannlowski, Udo$$b160
000875382 7001_ $$ade Geus, E. J. C.$$b161
000875382 7001_ $$aDePaulo, J Raymond$$b162
000875382 7001_ $$aDomenici, Enrico$$b163
000875382 7001_ $$aDomschke, Katharina$$b164
000875382 7001_ $$aEsko, Tõnu$$b165
000875382 7001_ $$aGrabe, Hans J$$b166
000875382 7001_ $$aHamilton, Steven P$$b167
000875382 7001_ $$aHayward, Caroline$$b168
000875382 7001_ $$aHeath, Andrew C$$b169
000875382 7001_ $$aKendler, Kenneth S$$b170
000875382 7001_ $$aKloiber, Stefan$$b171
000875382 7001_ $$aLewis, Glyn$$b172
000875382 7001_ $$aLi, Qingqin S$$b173
000875382 7001_ $$aLucae, Susanne$$b174
000875382 7001_ $$aMadden, Pamela A F$$b175
000875382 7001_ $$aMagnusson, Patrik K$$b176
000875382 7001_ $$aMartin, Nicholas G$$b177
000875382 7001_ $$aMetspalu, Andres$$b178
000875382 7001_ $$aMors, Ole$$b179
000875382 7001_ $$aMortensen, Preben Bo$$b180
000875382 7001_ $$aMüller-Myhsok, Bertram$$b181
000875382 7001_ $$aNordentoft, Merete$$b182
000875382 7001_ $$aNöthen, Markus M$$b183
000875382 7001_ $$aO'Donovan, Michael C$$b184
000875382 7001_ $$aPaciga, Sara A$$b185
000875382 7001_ $$aPedersen, Nancy L$$b186
000875382 7001_ $$aPenninx, Brenda W J H$$b187
000875382 7001_ $$aPerlis, Roy H$$b188
000875382 7001_ $$aPorteous, David J$$b189
000875382 7001_ $$aPotash, James B$$b190
000875382 7001_ $$aPreisig, Martin$$b191
000875382 7001_ $$aRietschel, Marcella$$b192
000875382 7001_ $$aSchaefer, Catherine$$b193
000875382 7001_ $$aSchulze, Thomas G$$b194
000875382 7001_ $$aSmoller, Jordan W$$b195
000875382 7001_ $$aStefansson, Kari$$b196
000875382 7001_ $$aTiemeier, Henning$$b197
000875382 7001_ $$aUher, Rudolf$$b198
000875382 7001_ $$aVölzke, Henry$$b199
000875382 7001_ $$aWeissman, Myrna M$$b200
000875382 7001_ $$aWerge, Thomas$$b201
000875382 7001_ $$aLewis, Cathryn M$$b202
000875382 7001_ $$aLevinson, Douglas F$$b203
000875382 7001_ $$aBreen, Gerome$$b204
000875382 7001_ $$aBørglum, Anders D$$b205
000875382 7001_ $$aSullivan, Patrick F$$b206
000875382 773__ $$0PERI:(DE-600)2553671-0$$a10.1038/s41467-020-16022-0$$gVol. 11, no. 1, p. 2301$$n1$$p2301$$tNature Communications$$v11$$x2041-1723$$y2020
000875382 8564_ $$uhttps://juser.fz-juelich.de/record/875382/files/Shen_etal_Nat.Comun_2020.pdf$$yOpenAccess
000875382 8564_ $$uhttps://juser.fz-juelich.de/record/875382/files/Shen_etal_Nat.Comun_2020.pdf?subformat=pdfa$$xpdfa$$yOpenAccess
000875382 909CO $$ooai:juser.fz-juelich.de:875382$$pdnbdelivery$$pdriver$$pVDB$$popen_access$$popenaire
000875382 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)140234$$aForschungszentrum Jülich$$b159$$kFZJ
000875382 9131_ $$0G:(DE-HGF)POF3-571$$1G:(DE-HGF)POF3-570$$2G:(DE-HGF)POF3-500$$3G:(DE-HGF)POF3$$4G:(DE-HGF)POF$$aDE-HGF$$bKey Technologies$$lDecoding the Human Brain$$vConnectivity and Activity$$x0
000875382 9141_ $$y2020
000875382 915__ $$0StatID:(DE-HGF)0200$$2StatID$$aDBCoverage$$bSCOPUS
000875382 915__ $$0StatID:(DE-HGF)1030$$2StatID$$aDBCoverage$$bCurrent Contents - Life Sciences
000875382 915__ $$0LIC:(DE-HGF)CCBY4$$2HGFVOC$$aCreative Commons Attribution CC BY 4.0
000875382 915__ $$0StatID:(DE-HGF)1040$$2StatID$$aDBCoverage$$bZoological Record
000875382 915__ $$0StatID:(DE-HGF)0100$$2StatID$$aJCR$$bNAT COMMUN : 2017
000875382 915__ $$0StatID:(DE-HGF)9910$$2StatID$$aIF >= 10$$bNAT COMMUN : 2017
000875382 915__ $$0StatID:(DE-HGF)0501$$2StatID$$aDBCoverage$$bDOAJ Seal
000875382 915__ $$0StatID:(DE-HGF)0500$$2StatID$$aDBCoverage$$bDOAJ
000875382 915__ $$0StatID:(DE-HGF)0110$$2StatID$$aWoS$$bScience Citation Index
000875382 915__ $$0StatID:(DE-HGF)0111$$2StatID$$aWoS$$bScience Citation Index Expanded
000875382 915__ $$0StatID:(DE-HGF)1150$$2StatID$$aDBCoverage$$bCurrent Contents - Physical, Chemical and Earth Sciences
000875382 915__ $$0StatID:(DE-HGF)0150$$2StatID$$aDBCoverage$$bWeb of Science Core Collection
000875382 915__ $$0StatID:(DE-HGF)0510$$2StatID$$aOpenAccess
000875382 915__ $$0StatID:(DE-HGF)0030$$2StatID$$aPeer Review$$bDOAJ : Blind peer review
000875382 915__ $$0StatID:(DE-HGF)1060$$2StatID$$aDBCoverage$$bCurrent Contents - Agriculture, Biology and Environmental Sciences
000875382 915__ $$0StatID:(DE-HGF)0310$$2StatID$$aDBCoverage$$bNCBI Molecular Biology Database
000875382 915__ $$0StatID:(DE-HGF)1050$$2StatID$$aDBCoverage$$bBIOSIS Previews
000875382 915__ $$0StatID:(DE-HGF)0300$$2StatID$$aDBCoverage$$bMedline
000875382 915__ $$0StatID:(DE-HGF)0320$$2StatID$$aDBCoverage$$bPubMed Central
000875382 915__ $$0StatID:(DE-HGF)0199$$2StatID$$aDBCoverage$$bClarivate Analytics Master Journal List
000875382 9201_ $$0I:(DE-Juel1)INM-1-20090406$$kINM-1$$lStrukturelle und funktionelle Organisation des Gehirns$$x0
000875382 980__ $$ajournal
000875382 980__ $$aVDB
000875382 980__ $$aUNRESTRICTED
000875382 980__ $$aI:(DE-Juel1)INM-1-20090406
000875382 9801_ $$aFullTexts