% IMPORTANT: The following is UTF-8 encoded.  This means that in the presence
% of non-ASCII characters, it will not work with BibTeX 0.99 or older.
% Instead, you should use an up-to-date BibTeX implementation like “bibtex8” or
% “biber”.

@ARTICLE{Shen:875382,
      author       = {Shen, Xueyi and Howard, David M and Adams, Mark J and Hill,
                      W David and Clarke, Toni-Kim and Deary, Ian J and Whalley,
                      Heather C and McIntosh, Andrew M and Adams, Mark J and
                      Clarke, Toni-Kim and McIntosh, Andrew M and Deary, Ian J and
                      Wray, Naomi R and Ripke, Stephan and Mattheisen, Manuel and
                      Trzaskowski, Maciej and Byrne, Enda M and Abdellaoui, Abdel
                      and Agerbo, Esben and Air, Tracy M and Andlauer, Till F M
                      and Bacanu, Silviu-Alin and Bækvad-Hansen, Marie and
                      Beekman, Aartjan T F and Bigdeli, Tim B and Binder,
                      Elisabeth B and Bryois, Julien and Buttenschøn, Henriette N
                      and Bybjerg-Grauholm, Jonas and Cai, Na and Castelao,
                      Enrique and Christensen, Jane Hvarregaard and Coleman,
                      Jonathan R I and Colodro-Conde, Lucía and Couvy-Duchesne,
                      Baptiste and Craddock, Nick and Crawford, Gregory E and
                      Davies, Gail and Degenhardt, Franziska and Derks, Eske M and
                      Direk, Nese and Dolan, Conor V and Dunn, Erin C and Eley,
                      Thalia C and Escott-Price, Valentina and Kiadeh, Farnush
                      Farhadi Hassan and Finucane, Hilary K and Foo, Jerome C and
                      Forstner, Andreas J and Frank, Josef and Gaspar, Héléna A
                      and Gill, Michael and Goes, Fernando S and Gordon, Scott D
                      and Grove, Jakob and Hall, Lynsey S and Hansen, Christine
                      Søholm and Hansen, Thomas F and Herms, Stefan and Hickie,
                      Ian B and Hoffmann, Per and Homuth, Georg and Horn, Carsten
                      and Hottenga, Jouke-Jan and Hougaard, David M and Howard,
                      David M and Ising, Marcus and Jansen, Rick and Jones, Ian
                      and Jones, Lisa A and Jorgenson, Eric and Knowles, James A
                      and Kohane, Isaac S and Kraft, Julia and Kretzschmar, Warren
                      W and Kutalik, Zoltán and Li, Yihan and Lind, Penelope A
                      and MacIntyre, Donald J and MacKinnon, Dean F and Maier,
                      Robert M and Maier, Wolfgang and Marchini, Jonathan and
                      Mbarek, Hamdi and McGrath, Patrick and McGuffin, Peter and
                      Medland, Sarah E and Mehta, Divya and Middeldorp, Christel M
                      and Mihailov, Evelin and Milaneschi, Yuri and Milani, Lili
                      and Mondimore, Francis M and Montgomery, Grant W and
                      Mostafavi, Sara and Mullins, Niamh and Nauck, Matthias and
                      Ng, Bernard and Nivard, Michel G and Nyholt, Dale R and
                      O'Reilly, Paul F and Oskarsson, Hogni and Owen, Michael J
                      and Painter, Jodie N and Pedersen, Carsten Bøcker and
                      Pedersen, Marianne Giørtz and Peterson, Roseann E and
                      Pettersson, Erik and Peyrot, Wouter J and Pistis, Giorgio
                      and Posthuma, Danielle and Quiroz, Jorge A and Qvist, Per
                      and Rice, John P and Riley, Brien P and Rivera, Margarita
                      and Mirza, Saira Saeed and Schoevers, Robert and Schulte,
                      Eva C and Shen, Ling and Shi, Jianxin and Shyn, Stanley I
                      and Sigurdsson, Engilbert and Sinnamon, Grant C B and Smit,
                      Johannes H and Smith, Daniel J and Stefansson, Hreinn and
                      Steinberg, Stacy and Streit, Fabian and Strohmaier, Jana and
                      Tansey, Katherine E and Teismann, Henning and Teumer,
                      Alexander and Thompson, Wesley and Thomson, Pippa A and
                      Thorgeirsson, Thorgeir E and Traylor, Matthew and Treutlein,
                      Jens and Trubetskoy, Vassily and Uitterlinden, Andrés G and
                      Umbricht, Daniel and Auwera, Sandra Van der and van Hemert,
                      Albert M and Viktorin, Alexander and Visscher, Peter M and
                      Wang, Yunpeng and Webb, Bradley T and Weinsheimer, Shantel
                      Marie and Wellmann, Jürgen and Willemsen, Gonneke and Witt,
                      Stephanie H and Wu, Yang and Xi, Hualin S and Yang, Jian and
                      Zhang, Futao and Arolt, Volker and Baune, Bernhard T and
                      Berger, Klaus and Boomsma, Dorret I and Cichon, Sven and
                      Dannlowski, Udo and de Geus, E. J. C. and DePaulo, J Raymond
                      and Domenici, Enrico and Domschke, Katharina and Esko, Tõnu
                      and Grabe, Hans J and Hamilton, Steven P and Hayward,
                      Caroline and Heath, Andrew C and Kendler, Kenneth S and
                      Kloiber, Stefan and Lewis, Glyn and Li, Qingqin S and Lucae,
                      Susanne and Madden, Pamela A F and Magnusson, Patrik K and
                      Martin, Nicholas G and Metspalu, Andres and Mors, Ole and
                      Mortensen, Preben Bo and Müller-Myhsok, Bertram and
                      Nordentoft, Merete and Nöthen, Markus M and O'Donovan,
                      Michael C and Paciga, Sara A and Pedersen, Nancy L and
                      Penninx, Brenda W J H and Perlis, Roy H and Porteous, David
                      J and Potash, James B and Preisig, Martin and Rietschel,
                      Marcella and Schaefer, Catherine and Schulze, Thomas G and
                      Smoller, Jordan W and Stefansson, Kari and Tiemeier, Henning
                      and Uher, Rudolf and Völzke, Henry and Weissman, Myrna M
                      and Werge, Thomas and Lewis, Cathryn M and Levinson, Douglas
                      F and Breen, Gerome and Børglum, Anders D and Sullivan,
                      Patrick F},
      title        = {{A} phenome-wide association and {M}endelian
                      {R}andomisation study of polygenic risk for depression in
                      {UK} {B}iobank.},
      journal      = {Nature Communications},
      volume       = {11},
      number       = {1},
      issn         = {2041-1723},
      address      = {[London]},
      publisher    = {Nature Publishing Group UK},
      reportid     = {FZJ-2020-01993},
      pages        = {2301},
      year         = {2020},
      abstract     = {Depression is a leading cause of worldwide disability but
                      there remains considerable uncertainty regarding its neural
                      and behavioural associations. Here, using non-overlapping
                      Psychiatric Genomics Consortium (PGC) datasets as a
                      reference, we estimate polygenic risk scores for depression
                      (depression-PRS) in a discovery (N = 10,674) and
                      replication (N = 11,214) imaging sample from UK Biobank.
                      We report 77 traits that are significantly associated with
                      depression-PRS, in both discovery and replication analyses.
                      Mendelian Randomisation analysis supports a potential causal
                      effect of liability to depression on brain white matter
                      microstructure (β: 0.125 to 0.868, pFDR < 0.043).
                      Several behavioural traits are also associated with
                      depression-PRS (β: 0.014 to 0.180, pFDR: 0.049 to
                      1.28 × 10-14) and we find a significant and positive
                      interaction between depression-PRS and adverse environmental
                      exposures on mental health outcomes. This study reveals
                      replicable associations between depression-PRS and white
                      matter microstructure. Our results indicate that white
                      matter microstructure differences may be a causal
                      consequence of liability to depression.},
      cin          = {INM-1},
      ddc          = {500},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32385265},
      UT           = {WOS:000533936800025},
      doi          = {10.1038/s41467-020-16022-0},
      url          = {https://juser.fz-juelich.de/record/875382},
}