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| 001 | 875382 | ||
| 005 | 20210130004925.0 | ||
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| 041 | _ | _ | |a eng |
| 082 | _ | _ | |a 500 |
| 100 | 1 | _ | |a Shen, Xueyi |0 0000-0002-0538-4774 |b 0 |
| 245 | _ | _ | |a A phenome-wide association and Mendelian Randomisation study of polygenic risk for depression in UK Biobank. |
| 260 | _ | _ | |a [London] |c 2020 |b Nature Publishing Group UK |
| 336 | 7 | _ | |a article |2 DRIVER |
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| 336 | 7 | _ | |a Journal Article |b journal |m journal |0 PUB:(DE-HGF)16 |s 1589456462_11909 |2 PUB:(DE-HGF) |
| 336 | 7 | _ | |a ARTICLE |2 BibTeX |
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| 336 | 7 | _ | |a Journal Article |0 0 |2 EndNote |
| 520 | _ | _ | |a Depression is a leading cause of worldwide disability but there remains considerable uncertainty regarding its neural and behavioural associations. Here, using non-overlapping Psychiatric Genomics Consortium (PGC) datasets as a reference, we estimate polygenic risk scores for depression (depression-PRS) in a discovery (N = 10,674) and replication (N = 11,214) imaging sample from UK Biobank. We report 77 traits that are significantly associated with depression-PRS, in both discovery and replication analyses. Mendelian Randomisation analysis supports a potential causal effect of liability to depression on brain white matter microstructure (β: 0.125 to 0.868, pFDR < 0.043). Several behavioural traits are also associated with depression-PRS (β: 0.014 to 0.180, pFDR: 0.049 to 1.28 × 10-14) and we find a significant and positive interaction between depression-PRS and adverse environmental exposures on mental health outcomes. This study reveals replicable associations between depression-PRS and white matter microstructure. Our results indicate that white matter microstructure differences may be a causal consequence of liability to depression. |
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| 700 | 1 | _ | |a Whalley, Heather C |0 0000-0002-4505-8869 |b 6 |
| 700 | 1 | _ | |a McIntosh, Andrew M |0 0000-0002-0198-4588 |b 7 |e Corresponding author |
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| 773 | _ | _ | |a 10.1038/s41467-020-16022-0 |g Vol. 11, no. 1, p. 2301 |0 PERI:(DE-600)2553671-0 |n 1 |p 2301 |t Nature Communications |v 11 |y 2020 |x 2041-1723 |
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