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@ARTICLE{Stengelin:875439,
      author       = {Stengelin, Elena and Kuzmina, Alena and Beltramo, Guillermo
                      L. and Koziol, Martha F. and Besch, Laura and Schröder,
                      Romina and Unger, Ronald E. and Tremel, Wolfgang and
                      Seiffert, Sebastian},
      title        = {{B}one {S}caffolds {B}ased on {D}egradable
                      {V}aterite/{PEG}‐{C}omposite {M}icrogels},
      journal      = {Advanced healthcare materials},
      volume       = {9},
      number       = {11},
      issn         = {2192-2659},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2020-02034},
      pages        = {1901820},
      year         = {2020},
      abstract     = {Vaterite, a metastable modification of calcium carbonate,
                      embedded in a flexible microgel packaging with adjustable
                      mechanical properties, functionality, and biocompatibility,
                      provides a powerful scaffolding for bone tissue
                      regeneration, as it is easily convertible to bone‐like
                      hydroxyapatite (HA). In this study, the synthesis and
                      physical analysis of a packaging material to encapsulate
                      vaterite particles and osteoblast cells into monodisperse,
                      sub‐millimeter‐sized microgels, is described whereby a
                      systematic approach is used to tailor the microgel
                      properties. The size and shape of the microgels is
                      controlled via droplet‐based microfluidics. Key
                      requirements for the polymer system, such as absence of
                      cytotoxicity as well as biocompatibility and
                      biodegradability, are accomplished with functionalized
                      poly(ethylene glycol) (PEG), which reacts in a
                      cytocompatible thiol–ene Michael addition. On a mesoscopic
                      level, the microgel stiffness and gelation times are
                      adjusted to obtain high cellular viabilities. The
                      co‐encapsulation of living cells provides i) an in vitro
                      platform for the study of cellular metabolic processes which
                      can be applied to bone formation and ii) an in vitro
                      foundation for novel tissue‐regenerative therapies.
                      Finally, the degradability of the microgels at physiological
                      conditions caused by hydrolysis‐sensitive ester groups in
                      the polymer network is examined.},
      cin          = {IBI-2},
      ddc          = {610},
      cid          = {I:(DE-Juel1)IBI-2-20200312},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32378355},
      UT           = {WOS:000530631000001},
      doi          = {10.1002/adhm.201901820},
      url          = {https://juser.fz-juelich.de/record/875439},
}