%0 Journal Article
%A Vliegenthart, Gerard A.
%A Ravichandran, Arvind
%A Ripoll, Marisol
%A Auth, Thorsten
%A Gompper, Gerhard
%T Filamentous active matter: Band formation, bending, buckling, and defects
%J Science advances
%V 6
%N 30
%@ 2375-2548
%C Washington, DC [u.a.]
%I Assoc.
%M FZJ-2020-02037
%P eaaw9975
%D 2020
%X Motor proteins drive persistent motion and self-organization of cytoskeletal filaments. However, state-of-the-art microscopy techniques and continuum modeling approaches focus on large length and time scales. Here, we perform component-based computer simulations of polar filaments and molecular motors linking microscopic interactions and activity to self-organization and dynamics from the filament level up to the mesoscopic domain level. Dynamic filament cross-linking and sliding and excluded-volume interactions promote formation of bundles at small densities and of active polar nematics at high densities. A buckling-type instability sets the size of polar domains and the density of topological defects. We predict a universal scaling of the active diffusion coefficient and the domain size with activity, and its dependence on parameters like motor concentration and filament persistence length. Our results provide a microscopic understanding of cytoplasmic streaming in cells and help to develop design strategies for novel engineered active materials.
%F PUB:(DE-HGF)16
%9 Journal Article
%$ pmid:32832652
%U <Go to ISI:>//WOS:000552228100001
%R 10.1126/sciadv.aaw9975
%U https://juser.fz-juelich.de/record/875442