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@ARTICLE{Hillringhaus:875444,
      author       = {Hillringhaus, Sebastian and Dasanna, Anil K and Gompper,
                      Gerhard and Fedosov, Dmitry A},
      title        = {{S}tochastic bond dynamics facilitates alignment of malaria
                      parasite at erythrocyte membrane upon invasion},
      journal      = {eLife},
      volume       = {9},
      issn         = {2050-084X},
      address      = {Cambridge},
      publisher    = {eLife Sciences Publications},
      reportid     = {FZJ-2020-02039},
      pages        = {e56500},
      year         = {2020},
      abstract     = {Malaria parasites invade healthy red blood cells (RBCs)
                      during the blood stage of the disease. Even though parasites
                      initially adhere to RBCs with a random orientation, they
                      need to align their apex toward the membrane in order to
                      start the invasion process. Using hydrodynamic simulations
                      of a RBC and parasite, where both interact through discrete
                      stochastic bonds, we show that parasite alignment is
                      governed by the combination of RBC membrane deformability
                      and dynamics of adhesion bonds. The stochastic nature of
                      bond-based interactions facilitates a diffusive-like
                      re-orientation of the parasite at the RBC membrane, while
                      RBC deformation aids in the establishment of apex-membrane
                      contact through partial parasite wrapping by the membrane.
                      This bond-based model for parasite adhesion quantitatively
                      captures alignment times measured experimentally and
                      demonstrates that alignment times increase drastically with
                      increasing rigidity of the RBC membrane. Our results suggest
                      that the alignment process is mediated simply by passive
                      parasite adhesion.},
      cin          = {IBI-5 / JARA-HPC},
      ddc          = {600},
      cid          = {I:(DE-Juel1)IBI-5-20200312 / $I:(DE-82)080012_20140620$},
      pnm          = {553 - Physical Basis of Diseases (POF3-553) / Formation of
                      Polymer-Particle Aggregates in Blood Flow
                      $(jiff44_20180501)$},
      pid          = {G:(DE-HGF)POF3-553 / $G:(DE-Juel1)jiff44_20180501$},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32420874},
      UT           = {WOS:000538460900001},
      doi          = {10.7554/eLife.56500},
      url          = {https://juser.fz-juelich.de/record/875444},
}