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000875458 1001_ $$0P:(DE-Juel1)156479$$aStegmayr, Carina$$b0$$eCorresponding author
000875458 245__ $$aInvestigation of Cerebral O-(2-[$^{18}$F]Fluoroethyl)-L-Tyrosine Uptake in Rat Epilepsy Models
000875458 260__ $$aNew York [u.a.]$$bSpringer$$c2020
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000875458 520__ $$aA recent study reported on high, longer lasting and finally reversible cerebral uptake of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) induced by epileptic activity. Therefore, we examined cerebral [18F]FET uptake in two chemically induced rat epilepsy models and in patients with focal epilepsy to further investigate whether this phenomenon represents a major pitfall in brain tumor diagnostics and whether [18F]FET may be a potential marker to localize epileptic foci.Five rats underwent kainic acid titration to exhibit 3 to 3.5 h of class IV–V motor seizures (status epilepticus, SE). Rats underwent 4× [18F]FET PET and 4× MRI on the following 25 days. Six rats underwent kindling with pentylenetetrazol (PTZ) 3 to 8×/week over 10 weeks, and hence, seizures increased from class I to class IV. [18F]FET PET and MRI were performed regularly on days with and without seizures. Four rats served as healthy controls. Additionally, five patients with focal epilepsy underwent [18F]FET PET within 12 days after the last documented seizure.No abnormalities in [18F]FET PET or MRI were detected in the kindling model. The SE model showed significantly decreased [18F]FET uptake 3 days after SE in all examined brain regions, and especially in the amygdala region, which normalized within 2 weeks. Corresponding signal alterations in T2-weighted MRI were noted in the amygdala and hippocampus, which recovered 24 days post-SE. No abnormality of cerebral [18F]FET uptake was noted in the epilepsy patients.There was no evidence for increased cerebral [18F]FET uptake after epileptic seizures neither in the rat models nor in patients. The SE model even showed decreased [18F]FET uptake throughout the brain. We conclude that epileptic seizures per se do not cause a longer lasting increased [18F]FET accumulation and are unlikely to be a major cause of pitfall for brain tumor diagnostics.
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000875458 7001_ $$0P:(DE-Juel1)164356$$aChoi, Chang-Hoon$$b2$$ufzj
000875458 7001_ $$0P:(DE-Juel1)173023$$aBurda, Nicole$$b3$$ufzj
000875458 7001_ $$0P:(DE-Juel1)131627$$aStoffels, Gabriele$$b4$$ufzj
000875458 7001_ $$0P:(DE-HGF)0$$aFilß, Christian$$b5
000875458 7001_ $$0P:(DE-Juel1)144347$$aWilluweit, Antje$$b6$$ufzj
000875458 7001_ $$0P:(DE-Juel1)166419$$aNeumaier, Bernd$$b7$$ufzj
000875458 7001_ $$0P:(DE-Juel1)132315$$aHeinzel, Alexander$$b8$$ufzj
000875458 7001_ $$0P:(DE-Juel1)131794$$aShah, N. Jon$$b9$$ufzj
000875458 7001_ $$0P:(DE-Juel1)132318$$aMottaghy, Felix M.$$b10$$ufzj
000875458 7001_ $$0P:(DE-Juel1)131777$$aLangen, Karl-Josef$$b11$$ufzj
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