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| Hauptseite > Publikationsdatenbank > Investigation of Cerebral O-(2-[$^{18}$F]Fluoroethyl)-L-Tyrosine Uptake in Rat Epilepsy Models > print |
| Hauptseite > Publikationsdatenbank > Investigation of Cerebral O-(2-[$^{18}$F]Fluoroethyl)-L-Tyrosine Uptake in Rat Epilepsy Models > print |
| 001 | 875458 | ||
| 005 | 20220930130239.0 | ||
| 024 | 7 | _ | |a 10.1007/s11307-020-01503-x |2 doi |
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| 037 | _ | _ | |a FZJ-2020-02050 |
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| 100 | 1 | _ | |a Stegmayr, Carina |0 P:(DE-Juel1)156479 |b 0 |e Corresponding author |
| 245 | _ | _ | |a Investigation of Cerebral O-(2-[$^{18}$F]Fluoroethyl)-L-Tyrosine Uptake in Rat Epilepsy Models |
| 260 | _ | _ | |a New York [u.a.] |c 2020 |b Springer |
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| 520 | _ | _ | |a A recent study reported on high, longer lasting and finally reversible cerebral uptake of O-(2-[18F]fluoroethyl)-L-tyrosine ([18F]FET) induced by epileptic activity. Therefore, we examined cerebral [18F]FET uptake in two chemically induced rat epilepsy models and in patients with focal epilepsy to further investigate whether this phenomenon represents a major pitfall in brain tumor diagnostics and whether [18F]FET may be a potential marker to localize epileptic foci.Five rats underwent kainic acid titration to exhibit 3 to 3.5 h of class IV–V motor seizures (status epilepticus, SE). Rats underwent 4× [18F]FET PET and 4× MRI on the following 25 days. Six rats underwent kindling with pentylenetetrazol (PTZ) 3 to 8×/week over 10 weeks, and hence, seizures increased from class I to class IV. [18F]FET PET and MRI were performed regularly on days with and without seizures. Four rats served as healthy controls. Additionally, five patients with focal epilepsy underwent [18F]FET PET within 12 days after the last documented seizure.No abnormalities in [18F]FET PET or MRI were detected in the kindling model. The SE model showed significantly decreased [18F]FET uptake 3 days after SE in all examined brain regions, and especially in the amygdala region, which normalized within 2 weeks. Corresponding signal alterations in T2-weighted MRI were noted in the amygdala and hippocampus, which recovered 24 days post-SE. No abnormality of cerebral [18F]FET uptake was noted in the epilepsy patients.There was no evidence for increased cerebral [18F]FET uptake after epileptic seizures neither in the rat models nor in patients. The SE model even showed decreased [18F]FET uptake throughout the brain. We conclude that epileptic seizures per se do not cause a longer lasting increased [18F]FET accumulation and are unlikely to be a major cause of pitfall for brain tumor diagnostics. |
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| 773 | _ | _ | |a 10.1007/s11307-020-01503-x |0 PERI:(DE-600)2079211-6 |p 1255–1265 |t Molecular imaging & biology |v 22 |y 2020 |x 1860-2002 |
| 856 | 4 | _ | |y OpenAccess |u https://juser.fz-juelich.de/record/875458/files/Stegmayr2020_Article_InvestigationOfCerebralO-2-%5B18.pdf |
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