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@ARTICLE{Kocher:877231,
      author       = {Kocher, Martin and Jockwitz, Christiane and Caspers, Svenja
                      and Schreiber, Jan and Farrher, Ezequiel and Stoffels,
                      Gabriele and Filss, Christian and Lohmann, Philipp and
                      Tscherpel, Caroline and Ruge, Maximilian I. and Fink, Gereon
                      R. and Shah, Nadim J. and Galldiks, Norbert and Langen,
                      Karl-Josef},
      title        = {{R}ole of the default mode resting-state network for
                      cognitive functioning in malignant glioma patients following
                      multimodal treatment},
      journal      = {NeuroImage: Clinical},
      volume       = {27},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2020-02058},
      pages        = {102287 -},
      year         = {2020},
      abstract     = {Progressive cognitive decline following multimodal
                      neurooncological treatment is a common observation in
                      patients suffering from malignant glioma. Alterations of the
                      default-mode network (DMN) represent a possible source of
                      impaired neurocognitive functioning and were analyzed in
                      these patients.Eighty patients (median age, 51 years) with
                      glioma (WHO grade IV glioblastoma, n=57; WHO grade III
                      anaplastic astrocytoma, n=13; WHO grade III anaplastic
                      oligodendroglioma, n=10) and ECOG performance score 0-1
                      underwent resting-state functional MRI (rs-fMRI) and
                      neuropsychological testing at a median interval of 13 months
                      (range, 1-114 months) after initiation of therapy. For
                      evaluation of structural and metabolic changes after
                      treatment, anatomical MRI and amino acid PET using
                      O-(2-[18F]fluoroethyl)-L-tyrosine (FET) were simultaneously
                      acquired to rs-fMRI on a hybrid MR/PET scanner. A cohort of
                      80 healthy subjects matched for gender, age, and educational
                      status served as controls.The connectivity pattern within
                      the DMN (12 nodes) of the glioma patients differed
                      significantly from that of the healthy subjects but did not
                      depend on age, tumor grade, time since treatment initiation,
                      presence of residual/recurrent tumor, number of chemotherapy
                      cycles received, or anticonvulsive medication. Small changes
                      in the connectivity pattern were observed in patients who
                      had more than one series of radiotherapy. In contrast,
                      structural tissue changes located at or near the tumor site
                      (including resection cavities, white matter lesions, edema,
                      and tumor tissue) had a strong negative impact on the
                      functional connectivity of the adjacent DMN nodes, resulting
                      in a marked dependence of the connectivity pattern on tumor
                      location. In the majority of neurocognitive domains, glioma
                      patients performed significantly worse than healthy
                      subjects. Correlation analysis revealed that reduced
                      connectivity in the left temporal and parietal DMN nodes was
                      associated with low performance in language processing and
                      verbal working memory. Furthermore, connectivity of the left
                      parietal DMN node also correlated with processing speed,
                      executive function, and verbal as well as visual working
                      memory. Overall DMN connectivity loss and cognitive decline
                      were less pronounced in patients with higher
                      education.Personalized treatment strategies for malignant
                      glioma patients should consider the left parietal and
                      temporal DMN nodes as vulnerable regions concerning
                      neurocognitive outcome.},
      cin          = {INM-4 / INM-1 / INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-4-20090406 / I:(DE-Juel1)INM-1-20090406 /
                      I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572) / 571 -
                      Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-572 / G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32540630},
      UT           = {WOS:000561851100004},
      doi          = {10.1016/j.nicl.2020.102287},
      url          = {https://juser.fz-juelich.de/record/877231},
}