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@ARTICLE{Pallast:877233,
      author       = {Pallast, Niklas and Wieters, Frederique and Nill, Marieke
                      and Fink, Gereon R. and Aswendt, Markus},
      title        = {{G}raph theoretical quantification of white matter
                      reorganization after cortical stroke in mice},
      journal      = {NeuroImage},
      volume       = {217},
      issn         = {1053-8119},
      address      = {Orlando, Fla.},
      publisher    = {Academic Press},
      reportid     = {FZJ-2020-02060},
      pages        = {116873 -},
      year         = {2020},
      abstract     = {Stroke is a devastating disease leading to cell death and
                      disconnection between neurons both locally and remote, often
                      resulting in severe long-term disability. Spontaneous
                      reorganization of areas and pathways not primarily affected
                      by ischemia is, however, associated with albeit limited
                      recovery of function. Quantitative mapping of whole-brain
                      changes of structural connectivity concerning the
                      ischemia-induced sensorimotor deficit and recovery thereof
                      would help to target structural plasticity in order to
                      improve rehabilitation. Currently, only in vivo diffusion
                      MRI can extract the structural whole-brain connectome
                      noninvasively. This approach is, however, used primarily in
                      human studies. Here, we applied atlas-based MRI analysis and
                      graph theory to DTI in wild-type mice with cortical stroke
                      lesions. Using a DTI network approach and graph theory, we
                      aimed at gaining insights into the dynamics of the
                      spontaneous reorganization after stroke related to the
                      recovery of function. We found evidence for altered
                      structural integrity of connections of specific brain
                      regions, including the breakdown of connections between
                      brain regions directly affected by stroke as well as
                      long-range rerouting of intra- and transhemispheric
                      connections related to improved sensorimotor behavior.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32380139},
      UT           = {WOS:000542369500014},
      doi          = {10.1016/j.neuroimage.2020.116873},
      url          = {https://juser.fz-juelich.de/record/877233},
}