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@ARTICLE{Dinkelbach:877314,
      author       = {Dinkelbach, Lars and Südmeyer, Martin and Hartmann,
                      Christian Johannes and Roeber, Sigrun and Arzberger, Thomas
                      and Felsberg, Jörg and Ferrea, Stefano and Moldovan,
                      Alexia-Sabine and Amunts, Katrin and Schnitzler, Alfons and
                      Caspers, Svenja},
      title        = {{S}omatosensory area 3b is selectively unaffected in
                      corticobasal syndrome: {C}ombining {MRI} and histology},
      journal      = {Neurobiology of aging},
      volume       = {94},
      issn         = {0197-4580},
      address      = {Amsterdam [u.a.]},
      publisher    = {Elsevier Science},
      reportid     = {FZJ-2020-02130},
      pages        = {89-100},
      year         = {2020},
      abstract     = {An increasing number of neuroimaging studies addressing
                      patients with corticobasal syndrome use macroscopic
                      definitions of brain regions. As a closer link to
                      functionally relevant units, we aimed at identifying
                      magnetic resonance–based atrophy patterns in regions
                      defined by probability maps of cortical microstructure. For
                      this purpose, three analyses were conducted: (1) Whole-brain
                      cortical thickness was compared between 36 patients with
                      corticobasal syndrome and 24 controls. A pattern of
                      pericentral atrophy was found, covering primary motor area
                      4, premotor area 6, and primary somatosensory areas 1, 2,
                      and 3a. Within the central region, only area 3b was without
                      atrophy. (2) In 18 patients, longitudinal measures with
                      follow-ups of up to 59 months (mean 21.3 ± 15.4) were
                      analyzed. Areas 1, 2, and 6 showed significantly faster
                      atrophy rates than primary somatosensory area 3b. (3) In an
                      individual autopsy case, longitudinal in vivo morphometry
                      and postmortem pathohistology were conducted. The rate of
                      magnetic resonance–based atrophy was significantly
                      correlated with tufted-astrocyte load in those
                      cytoarchitectonically defined regions also seen in the group
                      study, with area 3b being selectively unaffected.},
      cin          = {INM-1},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571) / HBP SGA2 -
                      Human Brain Project Specific Grant Agreement 2 (785907)},
      pid          = {G:(DE-HGF)POF3-571 / G:(EU-Grant)785907},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32593032},
      UT           = {WOS:000563977000012},
      doi          = {10.1016/j.neurobiolaging.2020.05.009},
      url          = {https://juser.fz-juelich.de/record/877314},
}