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@ARTICLE{Yuan:877330,
      author       = {Yuan, Xiaobo and Wolf, Nikolaus and Hondrich, Timm and
                      Shokoohimehr, Pegah and Milos, Frano and Glass, Manuel and
                      Mayer, Dirk and Maybeck, Vanessa and Prömpers, Michael and
                      Offenhäusser, Andreas and Wördenweber, Roger},
      title        = {{E}ngineering {B}iocompatible {I}nterfaces via
                      {C}ombinations of {O}xide {F}ilms and {O}rganic
                      {S}elf-{A}ssembled {M}onolayers},
      journal      = {ACS applied materials $\&$ interfaces},
      volume       = {12},
      number       = {14},
      issn         = {1944-8252},
      address      = {Washington, DC},
      publisher    = {Soc.},
      reportid     = {FZJ-2020-02146},
      pages        = {17121 - 17129},
      year         = {2020},
      abstract     = {In this paper, we demonstrate that cell adhesion and neuron
                      maturation can be guided by patterned oxide surfaces
                      functionalized with organic molecular layers. It is shown
                      that the difference in the surface potential of various
                      oxides (SiO2, Ta2O5, TiO2, and Al2O3) can be increased by
                      functionalization with a silane,
                      (3-aminopropyl)-triethoxysilane (APTES), which is deposited
                      from the gas phase on the oxide. Furthermore, it seems that
                      only physisorbed layers (no chemical binding) can be
                      achieved for some oxides (Ta2O5 and TiO2), whereas
                      self-assembled monolayers (SAM) form on other oxides (SiO2
                      and Al2O3). This does not only alter the surface potential
                      but also affects the neuronal cell growth. The already high
                      cell density on SiO2 is increased further by the chemically
                      bound APTES SAM, whereas the already low cell density on
                      Ta2O5 is even further reduced by the physisorbed APTES
                      layer. As a result, the cell density is ∼8 times greater
                      on SiO2 compared to Ta2O5, both coated with APTES.
                      Furthermore, neurons form the typical networks on SiO2,
                      whereas they tend to cluster to form neurospheres on Ta2O5.
                      Using lithographically patterned Ta2O5 layers on SiO2
                      substrates functionalized with APTES, the guided growth can
                      be transferred to complex patterns. Cell cultures and
                      molecular layers can easily be removed, and the cell
                      experiment can be repeated after functionalization of the
                      patterned oxide surface with APTES. Thus, the combination of
                      APTES-functionalized patterned oxides might offer a
                      promising way of achieving guided neuronal growth on robust
                      and reusable substrates.},
      cin          = {IBI-3},
      ddc          = {600},
      cid          = {I:(DE-Juel1)IBI-3-20200312},
      pnm          = {552 - Engineering Cell Function (POF3-552)},
      pid          = {G:(DE-HGF)POF3-552},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32186363},
      UT           = {WOS:000526583500121},
      doi          = {10.1021/acsami.0c02141},
      url          = {https://juser.fz-juelich.de/record/877330},
}