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@ARTICLE{Li:877413,
      author       = {Li, Jie and Kutovyi, Yurii and Zadorozhnyi, Ihor and
                      Boichuk, Nazarii and Vitusevich, Svetlana},
      title        = {{M}onitoring of {D}ynamic {P}rocesses during {D}etection of
                      {C}ardiac {B}iomarkers {U}sing {S}ilicon {N}anowire
                      {F}ield‐{E}ffect {T}ransistors},
      journal      = {Advanced materials interfaces},
      volume       = {7},
      number       = {15},
      issn         = {2196-7350},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2020-02176},
      pages        = {2000508},
      year         = {2020},
      abstract     = {Numerous sensitive nanobiosensors are reported for various
                      bioassay applications as a result of the development of
                      materials science and nanotechnology. Among these sensors,
                      nanowire (NW) field‐effect transistors (FETs) represent
                      one of the most promising practical biosensors for
                      ultrasensitive clinical diagnostic tools. Most studies
                      mainly focus on how to achieve a lower detection limit but
                      pay less attention to the long settling time effect for the
                      detection of very small concentrations of molecules in a
                      solution. In this study, single silicon NW FETs with
                      long‐term stability is fabricated to investigate the
                      settling time process at small concentrations of cardiac
                      biomarkers relevant to myocardial diseases. It is found that
                      the settling time strongly depends on the type of molecule,
                      its charge state and analyte concentrations. For low
                      concentrations, the time for measurement signals to settle
                      down is relatively long. Therefore, it is essential to
                      understand the settling time effect in Si NW FET‐based
                      biosensing processes to ensure the accuracy and reliability
                      of the detection signal. An alternative approach is
                      demonstrated to circumvent the long measurement time by
                      utilizing reaction kinetics parameters for the fast
                      determination of low‐concentration detection, which also
                      benefits the optimal balance between suitable detection time
                      and reliable detection results.},
      cin          = {IBI-3},
      ddc          = {600},
      cid          = {I:(DE-Juel1)IBI-3-20200312},
      pnm          = {523 - Controlling Configuration-Based Phenomena (POF3-523)},
      pid          = {G:(DE-HGF)POF3-523},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000537448200001},
      doi          = {10.1002/admi.202000508},
      url          = {https://juser.fz-juelich.de/record/877413},
}