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@ARTICLE{Wagels:877543,
      author       = {Wagels, Lisa and Votinov, Mikhail and Hüpen, Philippa and
                      Jung, Sonja and Montag, Christian and Habel, Ute},
      title        = {{S}ingle-{D}ose of {T}estosterone and the {MAOA} {VNTR}
                      {P}olymorphism {I}nfluence {E}motional and {B}ehavioral
                      {R}esponses in {M}en {D}uring a {N}on-social {F}rustration
                      {T}ask},
      journal      = {Frontiers in behavioral neuroscience},
      volume       = {14},
      issn         = {1662-5153},
      address      = {Lausanne},
      publisher    = {Frontiers Research Foundation},
      reportid     = {FZJ-2020-02279},
      pages        = {93},
      year         = {2020},
      abstract     = {Previous studies suggest that testosterone and several
                      neurotransmitters might interactively influence human
                      aggression. The current study aimed to test potential
                      interactions of a genetic variation linked to the catabolism
                      of serotonin, dopamine and norepinephrine and exogenous
                      testosterone on the reaction towards non-social provocation.
                      In total, 146 male participants were genotyped for a
                      prominent polymorphism of the monoamine oxidase A (MAOA)
                      gene resulting in a short and long variant. Participants
                      completed a non-social frustration task after receiving
                      either a testosterone or a placebo gel in a double-blind
                      set-up. Participants performed a non-social frustration
                      task, where they had to direct a virtually moving ball into
                      a barrel by pulling a joystick (neutral block). During a
                      frustration block, the joystick repeatedly did not respond
                      to participants’ reactions thereby causing failed trials
                      to which participants reacted with increased anger and
                      stronger pulling of the joystick. We analyzed the effect of
                      testosterone administration on emotion and behavior in
                      individuals who either carried a low (L) or high (H)
                      activity MAOA variant. Testosterone administration increased
                      provocation-related self-reported anger and abolished the
                      association between trait aggression and joystick deflection
                      in the frustration block. In MAOA-H carriers endogenous
                      testosterone levels at baseline were associated with
                      increased joystick deflection in both blocks. There was,
                      however, no interaction of testosterone administration and
                      genotype. Although preliminary, the results rather indicate
                      independent influences of exogenous testosterone
                      administration and MAOA, but support an interaction of
                      endogenous testosterone levels and MAOA genetics in a
                      frustration task. The administration of testosterone seems
                      to act on the subjective emotional experience in a provoking
                      situation, while endogenous testosterone levels increased
                      pulling impulses only in carriers of the MAOA-H variant.},
      cin          = {INM-10},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-10-20170113},
      pnm          = {899 - ohne Topic (POF3-899)},
      pid          = {G:(DE-HGF)POF3-899},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {32670031},
      UT           = {WOS:000549122900001},
      doi          = {10.3389/fnbeh.2020.00093},
      url          = {https://juser.fz-juelich.de/record/877543},
}