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@ARTICLE{Palomino:877574,
      author       = {Palomino, Oscar and Margreiter, Michael A. and Rossetti,
                      Giulia},
      title        = {{C}hallenges in {RNA} {R}egulation in {H}untington's
                      {D}isease: {I}nsights from {C}omputational {S}tudies},
      journal      = {Israel journal of chemistry},
      volume       = {60},
      number       = {7},
      issn         = {0021-2148},
      address      = {Weinheim},
      publisher    = {Wiley-VCH},
      reportid     = {FZJ-2020-02299},
      pages        = {681-693},
      year         = {2020},
      abstract     = {Novel therapeutic approaches are being developed to tackle
                      neurodegenerative diseases, due to the lack of efficiency of
                      the known druggable targets. For Huntington's disease, a
                      promising approach is the regulation of the RNA product.
                      This target would allow for a selective and effective
                      inhibition of the toxic effects exerted by the final nucleic
                      product and the coded protein. In this review, the current
                      state of the art of RNA regulation is discussed, with a
                      brief but insightful view on novel plausible targets. After
                      this, an emphasis on successful computational and
                      experimental approaches tailored in modeling and regulating
                      RNA aberrant behavior are extensively presented. Finally,
                      the application and limitations of current computational
                      methods are discussed, and possible avenues for improvement
                      are outlined.},
      cin          = {IAS-5 / INM-9 / JSC},
      ddc          = {540},
      cid          = {I:(DE-Juel1)IAS-5-20120330 / I:(DE-Juel1)INM-9-20140121 /
                      I:(DE-Juel1)JSC-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572) / 511 -
                      Computational Science and Mathematical Methods (POF3-511)},
      pid          = {G:(DE-HGF)POF3-572 / G:(DE-HGF)POF3-511},
      typ          = {PUB:(DE-HGF)16},
      UT           = {WOS:000540305000001},
      doi          = {10.1002/ijch.202000021},
      url          = {https://juser.fz-juelich.de/record/877574},
}