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@ARTICLE{Niessen:877609,
      author       = {Niessen, Eva and Ant, Jana M. and Bode, Stefan and Saliger,
                      Jochen and Karbe, Hans and Fink, Gereon R. and Stahl, Jutta
                      and Weiss-Blankenhorn, Peter},
      title        = {{P}reserved performance monitoring and error detection in
                      left hemisphere stroke},
      journal      = {NeuroImage: Clinical},
      volume       = {27},
      issn         = {2213-1582},
      address      = {[Amsterdam u.a.]},
      publisher    = {Elsevier},
      reportid     = {FZJ-2020-02324},
      pages        = {102307 -},
      year         = {2020},
      abstract     = {Depending on the lesion site, a stroke typically affects
                      various aspects of cognitive control. While executing a
                      task, the performance monitoring system constantly compares
                      an intended action plan with the executed action and thereby
                      registers inaccurate actions in case of any mismatch. When
                      errors occur, the performance monitoring system signals the
                      need for more cognitive control, which is most efficient
                      when the subject notices errors rather than processing them
                      subconsciously. The current study aimed to investigate
                      performance monitoring and error detection in a large sample
                      of patients with left hemisphere (LH) stroke.In addition to
                      clinical and neuropsychological tests, 24 LH stroke patients
                      and 32 healthy age-matched controls performed a Go/Nogo task
                      with simultaneous electroencephalography (EEG) measurements.
                      This set-up enabled us to compare performance monitoring at
                      the behavioral and the neural level. EEG data were analyzed
                      using event-related potentials [ERPs; e.g., the
                      error-related negativity (Ne/ERN) and error positivity (Pe)]
                      and additionally more sensitive whole-brain multivariate
                      pattern classification analyses (MVPA). We hypothesized that
                      LH stroke patients would show behavioural deficits in error
                      detection when compared to healthy controls, mirrored by
                      differences in neural signals, in particular reflected in
                      the Pe component.Interestingly, despite clinically relevant
                      cognitive deficits (e.g., aphasia and apraxia) including
                      executive dysfunction (trail making test), we did not
                      observe any behavioral impairments related to performance
                      monitoring and error processing in the current LH stroke
                      patients. Patients also showed similar results for Ne/ERN
                      and Pe components, compared to the control group, and a
                      highly similar prediction of errors from multivariate
                      signals. ERP abnormalities during stimulus processing (i.e.,
                      N2 and P3) demonstrated the specificity of these findings in
                      the current LH stroke patients. In contrast to previous
                      studies, by employing a relatively large patient sample, a
                      well-controlled experimental paradigm with a standardized
                      error signaling procedure, and advanced data analysis, we
                      were able to show that performance monitoring (of simple
                      actions) is a preserved cognitive control function in LH
                      stroke patients that might constitute a useful resource in
                      rehabilitative therapies for re-learning impeded functions.},
      cin          = {INM-3},
      ddc          = {610},
      cid          = {I:(DE-Juel1)INM-3-20090406},
      pnm          = {572 - (Dys-)function and Plasticity (POF3-572)},
      pid          = {G:(DE-HGF)POF3-572},
      typ          = {PUB:(DE-HGF)16},
      pubmed       = {pmid:32570207},
      UT           = {WOS:000561850400010},
      doi          = {10.1016/j.nicl.2020.102307},
      url          = {https://juser.fz-juelich.de/record/877609},
}