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000877614 005__ 20220930130243.0
000877614 0247_ $$2Handle$$a2128/25328
000877614 0247_ $$2URN$$aurn:nbn:de:0001-2020072231
000877614 0247_ $$2ISSN$$a1866-1807
000877614 020__ $$a978-3-95806-473-7
000877614 037__ $$aFZJ-2020-02329
000877614 041__ $$aEnglish
000877614 1001_ $$0P:(DE-Juel1)161201$$aStibane, Dennis$$b0$$eCorresponding author$$gmale$$ufzj
000877614 245__ $$aPostnatale Ontogenesestudie (Altersstudie) hinsichtlich der Zyto- und Rezeptorarchitektonik im visuellen Kortex bei der grünen Meerkatze$$f- 2020-07-22
000877614 260__ $$aJülich$$bForschungszentrum Jülich GmbH Zentralbibliothek, Verlag$$c2020
000877614 300__ $$a135 S.
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000877614 3367_ $$02$$2EndNote$$aThesis
000877614 3367_ $$0PUB:(DE-HGF)11$$2PUB:(DE-HGF)$$aDissertation / PhD Thesis$$bphd$$mphd$$s1595405051_1261
000877614 3367_ $$2DRIVER$$adoctoralThesis
000877614 4900_ $$aSchriften des Forschungszentrums Jülich. Reihe Schlüsseltechnologien / Key Technologies$$v219
000877614 502__ $$aRWTH Aachen, Diss., 2020$$bDr.$$cRWTH Aachen$$d2020
000877614 520__ $$aThe present work has focused on two main aspects. On the one hand, the boundaries and location of the primary visual cortex area V1 and other visual areas (V2v, V2d,V3v, V3d, V3A, V4v, V4d, V4A, V5 and V6) were investigated in the vervet monkey (Chlorocebus aethiops sabaeus) using an observer-independent, statistically testable cytoarchitectonical analysis of the regional and laminar differences in the distribution of cell bodies. A comparable map of the cortical visual system is currently only available for macaques, but not for Chlorocebus. The second part of the study included the quantification of the postnatal development of the density (in fmol/mg protein) of 20 different transmitter-receptor binding sites of all classical transmitter systems (glutamate, $\gamma$-aminobutyric acid [GABA], acetylcholine, dopamine, noradrenaline, serotonin) and of adenosine in these visual areas. Five age groups were selected (30,54, 90 days, 1 year and 4 years). Previous ontogenesis studies in primates have mostly been limited to the primary visual cortex and there is no multi-receptor analysis of ontogenesis in the visual system of this animal model. With regard to cytoarchitecture, the features of the areas were identified and were found to be similar to those described in the literature for rhesus monkeys. No differences in cytoarchitecture during postnatal development could be found. The analysis of the receptor binding sites showed significant changes. Specifically, densities were found to decrease within creasing age for the NMDA, kainate, mGluR2/3, GABA$_{A}$, GABA$_{B}$, M$_{2}$, M$_{3}$, AChN and α2 receptors. Conversely, GABA$_{A}$/BZ, 5-HT$_{2}$ and A$_{1}$ receptors showed an increase indensity with increasing age. Very different visual areas were affected. A cluster analysis to examine a possible classification of the visual areas into homogeneous clusters according to their receptor architectonic properties could also show that the areas cannot be divided into strictly separated groups, which suggests increased interaction between ventral and dorsal elements instead of a clear functional separation of these.
000877614 536__ $$0G:(DE-HGF)POF3-571$$a571 - Connectivity and Activity (POF3-571)$$cPOF3-571$$fPOF III$$x0
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000877614 9141_ $$y2020
000877614 9101_ $$0I:(DE-588b)5008462-8$$6P:(DE-Juel1)161201$$aForschungszentrum Jülich$$b0$$kFZJ
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000877614 920__ $$lyes
000877614 9201_ $$0I:(DE-Juel1)INM-1-20090406$$kINM-1$$lStrukturelle und funktionelle Organisation des Gehirns$$x0
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