TY  - THES
AU  - Stibane, Dennis
TI  - Postnatale Ontogenesestudie (Altersstudie) hinsichtlich der Zyto- und Rezeptorarchitektonik im visuellen Kortex bei der grünen Meerkatze
VL  - 219
PB  - RWTH Aachen
VL  - Dr.
CY  - Jülich
M1  - FZJ-2020-02329
SN  - 978-3-95806-473-7
T2  - Schriften des Forschungszentrums Jülich. Reihe Schlüsseltechnologien / Key Technologies
SP  - 135 S.
PY  - 2020
N1  - RWTH Aachen, Diss., 2020
AB  - The present work has focused on two main aspects. On the one hand, the boundaries and location of the primary visual cortex area V1 and other visual areas (V2v, V2d,V3v, V3d, V3A, V4v, V4d, V4A, V5 and V6) were investigated in the vervet monkey (Chlorocebus aethiops sabaeus) using an observer-independent, statistically testable cytoarchitectonical analysis of the regional and laminar differences in the distribution of cell bodies. A comparable map of the cortical visual system is currently only available for macaques, but not for Chlorocebus. The second part of the study included the quantification of the postnatal development of the density (in fmol/mg protein) of 20 different transmitter-receptor binding sites of all classical transmitter systems (glutamate, $\gamma$-aminobutyric acid [GABA], acetylcholine, dopamine, noradrenaline, serotonin) and of adenosine in these visual areas. Five age groups were selected (30,54, 90 days, 1 year and 4 years). Previous ontogenesis studies in primates have mostly been limited to the primary visual cortex and there is no multi-receptor analysis of ontogenesis in the visual system of this animal model. With regard to cytoarchitecture, the features of the areas were identified and were found to be similar to those described in the literature for rhesus monkeys. No differences in cytoarchitecture during postnatal development could be found. The analysis of the receptor binding sites showed significant changes. Specifically, densities were found to decrease within creasing age for the NMDA, kainate, mGluR2/3, GABA$_{A}$, GABA$_{B}$, M$_{2}$, M$_{3}$, AChN and α2 receptors. Conversely, GABA$_{A}$/BZ, 5-HT$_{2}$ and A$_{1}$ receptors showed an increase indensity with increasing age. Very different visual areas were affected. A cluster analysis to examine a possible classification of the visual areas into homogeneous clusters according to their receptor architectonic properties could also show that the areas cannot be divided into strictly separated groups, which suggests increased interaction between ventral and dorsal elements instead of a clear functional separation of these.
LB  - PUB:(DE-HGF)3 ; PUB:(DE-HGF)11
UR  - https://juser.fz-juelich.de/record/877614
ER  -