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@PHDTHESIS{Stibane:877614,
author = {Stibane, Dennis},
title = {{P}ostnatale {O}ntogenesestudie ({A}ltersstudie)
hinsichtlich der {Z}yto- und {R}ezeptorarchitektonik im
visuellen {K}ortex bei der grünen {M}eerkatze},
volume = {219},
school = {RWTH Aachen},
type = {Dr.},
address = {Jülich},
publisher = {Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag},
reportid = {FZJ-2020-02329},
isbn = {978-3-95806-473-7},
series = {Schriften des Forschungszentrums Jülich. Reihe
Schlüsseltechnologien / Key Technologies},
pages = {135 S.},
year = {2020},
note = {RWTH Aachen, Diss., 2020},
abstract = {The present work has focused on two main aspects. On the
one hand, the boundaries and location of the primary visual
cortex area V1 and other visual areas (V2v, V2d,V3v, V3d,
V3A, V4v, V4d, V4A, V5 and V6) were investigated in the
vervet monkey (Chlorocebus aethiops sabaeus) using an
observer-independent, statistically testable
cytoarchitectonical analysis of the regional and laminar
differences in the distribution of cell bodies. A comparable
map of the cortical visual system is currently only
available for macaques, but not for Chlorocebus. The second
part of the study included the quantification of the
postnatal development of the density (in fmol/mg protein) of
20 different transmitter-receptor binding sites of all
classical transmitter systems (glutamate,
$\gamma$-aminobutyric acid [GABA], acetylcholine, dopamine,
noradrenaline, serotonin) and of adenosine in these visual
areas. Five age groups were selected (30,54, 90 days, 1 year
and 4 years). Previous ontogenesis studies in primates have
mostly been limited to the primary visual cortex and there
is no multi-receptor analysis of ontogenesis in the visual
system of this animal model. With regard to
cytoarchitecture, the features of the areas were identified
and were found to be similar to those described in the
literature for rhesus monkeys. No differences in
cytoarchitecture during postnatal development could be
found. The analysis of the receptor binding sites showed
significant changes. Specifically, densities were found to
decrease within creasing age for the NMDA, kainate,
mGluR2/3, GABA$_{A}$, GABA$_{B}$, M$_{2}$, M$_{3}$, AChN and
α2 receptors. Conversely, GABA$_{A}$/BZ, 5-HT$_{2}$ and
A$_{1}$ receptors showed an increase indensity with
increasing age. Very different visual areas were affected. A
cluster analysis to examine a possible classification of the
visual areas into homogeneous clusters according to their
receptor architectonic properties could also show that the
areas cannot be divided into strictly separated groups,
which suggests increased interaction between ventral and
dorsal elements instead of a clear functional separation of
these.},
cin = {INM-1},
cid = {I:(DE-Juel1)INM-1-20090406},
pnm = {571 - Connectivity and Activity (POF3-571)},
pid = {G:(DE-HGF)POF3-571},
typ = {PUB:(DE-HGF)3 / PUB:(DE-HGF)11},
urn = {urn:nbn:de:0001-2020072231},
url = {https://juser.fz-juelich.de/record/877614},
}