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@PHDTHESIS{Stibane:877614,
      author       = {Stibane, Dennis},
      title        = {{P}ostnatale {O}ntogenesestudie ({A}ltersstudie)
                      hinsichtlich der {Z}yto- und {R}ezeptorarchitektonik im
                      visuellen {K}ortex bei der grünen {M}eerkatze},
      volume       = {219},
      school       = {RWTH Aachen},
      type         = {Dr.},
      address      = {Jülich},
      publisher    = {Forschungszentrum Jülich GmbH Zentralbibliothek, Verlag},
      reportid     = {FZJ-2020-02329},
      isbn         = {978-3-95806-473-7},
      series       = {Schriften des Forschungszentrums Jülich. Reihe
                      Schlüsseltechnologien / Key Technologies},
      pages        = {135 S.},
      year         = {2020},
      note         = {RWTH Aachen, Diss., 2020},
      abstract     = {The present work has focused on two main aspects. On the
                      one hand, the boundaries and location of the primary visual
                      cortex area V1 and other visual areas (V2v, V2d,V3v, V3d,
                      V3A, V4v, V4d, V4A, V5 and V6) were investigated in the
                      vervet monkey (Chlorocebus aethiops sabaeus) using an
                      observer-independent, statistically testable
                      cytoarchitectonical analysis of the regional and laminar
                      differences in the distribution of cell bodies. A comparable
                      map of the cortical visual system is currently only
                      available for macaques, but not for Chlorocebus. The second
                      part of the study included the quantification of the
                      postnatal development of the density (in fmol/mg protein) of
                      20 different transmitter-receptor binding sites of all
                      classical transmitter systems (glutamate,
                      $\gamma$-aminobutyric acid [GABA], acetylcholine, dopamine,
                      noradrenaline, serotonin) and of adenosine in these visual
                      areas. Five age groups were selected (30,54, 90 days, 1 year
                      and 4 years). Previous ontogenesis studies in primates have
                      mostly been limited to the primary visual cortex and there
                      is no multi-receptor analysis of ontogenesis in the visual
                      system of this animal model. With regard to
                      cytoarchitecture, the features of the areas were identified
                      and were found to be similar to those described in the
                      literature for rhesus monkeys. No differences in
                      cytoarchitecture during postnatal development could be
                      found. The analysis of the receptor binding sites showed
                      significant changes. Specifically, densities were found to
                      decrease within creasing age for the NMDA, kainate,
                      mGluR2/3, GABA$_{A}$, GABA$_{B}$, M$_{2}$, M$_{3}$, AChN and
                      α2 receptors. Conversely, GABA$_{A}$/BZ, 5-HT$_{2}$ and
                      A$_{1}$ receptors showed an increase indensity with
                      increasing age. Very different visual areas were affected. A
                      cluster analysis to examine a possible classification of the
                      visual areas into homogeneous clusters according to their
                      receptor architectonic properties could also show that the
                      areas cannot be divided into strictly separated groups,
                      which suggests increased interaction between ventral and
                      dorsal elements instead of a clear functional separation of
                      these.},
      cin          = {INM-1},
      cid          = {I:(DE-Juel1)INM-1-20090406},
      pnm          = {571 - Connectivity and Activity (POF3-571)},
      pid          = {G:(DE-HGF)POF3-571},
      typ          = {PUB:(DE-HGF)3 / PUB:(DE-HGF)11},
      urn          = {urn:nbn:de:0001-2020072231},
      url          = {https://juser.fz-juelich.de/record/877614},
}