TY  - JOUR
AU  - Valk, Sofie L.
AU  - Hoffstaedter, Felix
AU  - Camilleri, Julia
AU  - Kochunov, Peter
AU  - Yeo, B. T. Thomas
AU  - Eickhoff, Simon B.
TI  - Personality and local brain structure: their shared genetic basis and reproducibility
JO  - NeuroImage
VL  - 220
SN  - 1053-8119
CY  - Orlando, Fla.
PB  - Academic Press
M1  - FZJ-2020-02371
SP  - 117067 -
PY  - 2020
N1  - AcknowledgementsWe would like to thank the various contributors to the open access databases that our data was downloaded from. Specifically; HCP data were provided by the Human Connectome Project, Washington University, the University of Minnesota, and Oxford University Consortium (Principal Investigators: David Van Essen and Kamil Ugurbil;1U54MH091657) funded by the 16 NIH Institutes and Centers that support the NIH Blueprint for Neuroscience Research; and by the McDonnell Center for Systems Neuroscience at Washington University. GSP data were provided by the Brain Genomics Superstruct Project of Harvard University and the Massachusetts General Hospital, (Principal Investigators: Randy Buckner, Joshua Roffman, and Jordan Smoller), with support from the Center for Brain Science Neuroinformatics Research Group, the Athinoula A. Martinos Center for Biomedical Imaging, and the Center for Human Genetic Research. 20 individual investigators at Harvard and MGH generously contributed data to the overall project.For enhanced NKI, we would like to thank the principal support for the enhanced NKI-RS project is provided by the NIMH BRAINS R01MH094639-01 (PI Milham). Funding for key personnel was also provided in part by the New York State Office of Mental Health and Research Foundation for Mental Hygiene. Funding for the decompression and augmentation of administrative and phenotypic protocols provided by a grant from the Child Mind Institute (1FDN2012-1). Additional personnel support provided by the Center for the Developing Brain at the Child Mind Institute, as well as NIMH R01MH081218, R01MH083246, and R21MH084126. Project support also provided by the NKI Center for Advanced Brain Imaging (CABI), the Brain Research Foundation (Chicago, IL), and the Stavros Niarchos Foundation. Last, we want to thank L.C.Valk for proofreading the manuscript.
AB  - Local cortical architecture is highly heritable and distinct genes are associated with specific cortical regions. Total surface area has been shown to be genetically correlated with complex cognitive capacities, suggesting cortical brain structure is a viable endophenotype linking genes to behavior. However, to what extend local brain structure has a genetic association with cognitive and emotional functioning is incompletely understood. Here, we study the genetic correlation between personality traits and local cortical structure in a large-scale twin sample (Human Connectome Project, n=1102, 22-37y) and we evaluated whether observed associations reflect generalizable relationships between personality and local brain structure two independent age-matched samples (Brain Genomics Superstructure Project: n=925, age=19-35y, enhanced Nathan Kline Institute dataset: n=209, age: 19-39y). We found a genetic overlap between personality traits and local cortical structure in 10 of 18 observed phenotypic associations in predominantly frontal cortices. However, we only observed evidence in favor of replication for the negative association between surface area in medial prefrontal cortex and Neuroticism in both replication samples. Quantitative functional decoding indicated this region is implicated in emotional and socio-cognitive functional processes. In sum, our observations suggest that associations between local brain structure and personality are, in part, under genetic control. However, associations are weak and only the relation between frontal surface area and Neuroticism was consistently observed across three independent samples of young adults.
LB  - PUB:(DE-HGF)16
C6  - pmid:32574809
UR  - <Go to ISI:>//WOS:000579184700025
DO  - DOI:10.1016/j.neuroimage.2020.117067
UR  - https://juser.fz-juelich.de/record/877661
ER  -